摘要
目的探讨联合使用前列腺素E1对脓毒症患者的疗效,以及对促炎及抗炎因子水平的影响。方法将该院ICU的脓毒症患者120例分为A、B、C、D 4组,每组30例。在常规治疗基础上,A组加用前列腺素E1和血必净注射液,B组加用前列腺素E1,C组加用血必净注射液,D组只采用常规治疗。对比观察4组患者急性生理和慢性健康状况评分Ⅱ(APACHEⅡ)及Marshall评分、抗炎及促炎因子、机械通气时间、ICU治疗时间、28d病死率等变化。结果与治疗前比较,4组患者治疗后APACHEⅡ及Marshall评分均明显降低(P<0.05)。与B、C、D组比较,A组治疗后APACHEⅡ及Marshall评分、IL-1β、IL-6及TNF-α水平降低更明显(P<0.05),IL-10水平明显升高(P<0.05);机械通气时间、ICU住院时间明显较短(P<0.05),28d病死率明显较低(P<0.05)。结论前列腺素E1联合血必净注射液能有效抑制脓毒症患者体内炎性反应,促进患者恢复,降低病死亡率。
Objective To investigate the effects of prostaglandin E1 on proinflammatory and anti-inflammatory cytokines in sepsis patients.Methods One hundred and twenty cases of sepsis in ICU of our hospital were assigned to the groups：A,B,C and D,30 cases in each group.On the basis of conventional therapy,group A was added with prostaglandin E1＋ Xuebijing injection.The group was treated with prostaglandin E1,while the group C was treated with Xuebijing injection.The changes of APACHE Ⅱscore,Marshall score,anti-inflammatory and pro-inflammatory factors,mechanical ventilation time,ICU treatment time,28 dmortality rate in the 4grups were observed and compared among 4groups.Results The APACHE Ⅱ score and Marshall score after treatment in 4groups were significantly decreased compared with before freatment（P〈0.05）,Compared with the group B,C and D,The decrease of APACHE Ⅱ score,Marshace score,IL-1β,IL-6and TNF-αlevels was more significantly（P〈0.05）,While the IL-10 level was significantly increastol（P〈0.05）;duration of mechanical ventilation,length of stay ICU in were significantly shorter（P〈0.05）,28 dmortality was significantly lower（P〈0.05）.Conclusion Prostaglandin E1 combined with Xuebijing injection can effectively inhibit the inflammatory response in septic patients and promote the recovery of patients,reduces the mortality rate.
出处
《重庆医学》
CAS
北大核心
2017年第7期929-930,933,共3页
Chongqing medicine
