摘要
目的比较缬沙坦联合硝苯地平控释片与单独应用缬沙坦对治疗原发性高血压的临床疗效。方法将我院80例原发性高血压患者纳入本次的研究对象,分组方式为随机数字分组法,分为两组,一组采用单药治疗(缬沙坦),作为单一用药组,一组采用双联疗法(缬沙坦+硝苯地平控释片),作为联合用药组,比较两组患者的治疗效果和不良反应以及收缩压、舒张压和三酰甘油指标的变化。结果单一用药组的总有效率为77.50%,联合用药组的总有效率为95.00%,两组差异有统计学意义(P<0.05);单一用药组的不良反应发生率为20.00%,联合用药组的不良反应发生率为5.00%,两组差异有统计学意义(P<0.05);治疗后两组患者的收缩压、舒张压和三酰甘油指标均有效改善,联合用药组的改善情况优于单一用药组,两组差异有统计学意义(P<0.05)。结论在缬沙坦的基础上联合硝苯地平对治疗原发性高血压具有显著的效果,且安全性良好。
Objective To compare the clinical effect of Valsartan combined with Nifedipine Controlled Release Tablets and single Valsartan in treatment of primary hypertension. Methods 80 cases of patients with primary hypertension cured in our hospital were selected as the study objects. According to the random digital division method, they were divided into single drug group （treated with single Valsartan ） and combined drug group （ treated with Valsartan combined with Nifedipine Controlled Release Tablets）. Treatment effects and adverse reactions, as well as changes in systolic blood pressure, diastolic blood pressure and three glycerol index of the two groups were compared. Results The total effective rate of the single drug group was 77.50%, and the total effective rate of the combined drup group was about 95.00%, and there was significant difference between the two groups（P 〈 0.05）. The incidence of adverse reactions was 20.00% in the monotherapy group, and the incidence of adverse reactions in the combination drug group was about 5.00%, and the difference between the two groups was significant（P 〈 0.05）. After treatment, systolic blood pressure, diastolic blood pressure and the index of three glycerol in the two groups were effectively improved. The improvement situation og combined drug group was better than that of single drug group, the two groups had significant difference（P 〈 0.05）. Conclusion Valsartan combined with nifedipine controlled release tablets in treatment of primary hypertension has good effect. And its safety is good.
出处
《中国医药科学》
2017年第1期88-90,119,共4页
China Medicine And Pharmacy
