摘要
目的本试验旨在探讨与传统血液灌流方法相比,加强血液灌流对急性百草枯中毒患儿治疗作用及护理。方法采用随机对照研究方法,对该院2012年1月—2016年5月收治的118例急性百草枯中毒患儿的临床资料、治疗与护理措施进行分析和总结,所有患儿入院后给予常规治疗,并随机分为观察组(n=66)和对照组(n=52),入院2h内开始血液灌流,其中观察组给予加强血液灌流,对照组接受传统血液灌流方法。对比二组患儿服药剂量,首次就诊时间等基本指标,肝肾功能损害指标及远期病死率情况。结果二组患儿在服毒剂量,首次就诊时间间隔等方面比较差异均无统计学意义。与对照组相比,观察组患儿血浆百草枯浓度在治疗后12h较对照组明显降低,肝肾功能在入院后5d达到峰值,14d后逐渐降至低值,均低于对照组,病死率也低于对照组,差异有统计学意义(P<0.05)。结论加强血液灌流可有效清除体内百草枯,改善患儿预后。
Objective To observe the effect of trengthen Hemoperfusion Technology as the main composition in the therapy and the care for child patients with acute paraquat poisoning（APP）.Methods A prospective randomized controlled trial was conducted.118 child patients with APP admitted to author＇s hospital from January 2012 to May 2015 were randomly divided into test and control group.The test group（n=66）was given strengthen hemoperfusion technology,while the control group（n=52）was treaten with regular hemoperfusion technology,and also given the routine combined therapy.The poison volume,time for the first HP,liver and kidney functions,and mortality rate were observed in both groups.Results There were no significant differences in the poison volume and the time for the first HP between the two groups.The paraquat levels were gradually increased12 hours after admission.The alanine aminotransferase,blood urea nitrogen,serum creatinine and creatine kinase peaked on 5th day,and decreased at 14 days after poisoning.The injury to liver and kidney functions was significantly improved in control group compared with that in the test group（P〈0.05）.And the mortality rate was significantly lowered compared with control group（P〈0.05）.Conclusion The strengthen hemoperfusion technology can effectively remove the paraquat in plasma,and decrease the death rate of children at the same time.
出处
《中国煤炭工业医学杂志》
2017年第2期208-211,共4页
Chinese Journal of Coal Industry Medicine
关键词
百草枯
中毒
加强血液灌流
护理
Paraquat
Poisoning
Strengthen hemoperfusion technology
Nursing
