摘要
目的:比较培美曲塞单药和联合化学治疗(化疗)两种不同化疗方案在晚期复发性非小细胞肺癌(NSCLC)中的有效性和安全性。方法:纳入我院73例晚期复发性NSCLC患者作为研究对象,根据治疗方案不同,37例接受培美曲塞单药化疗(单药组),另36例接受培美曲塞联合铂类化疗(联合组)。结果:单药组与联合组客观缓解率(43.24%vs 38.89%)及疾病控制率(89.19%vs 86.11%)比较,无显著性差异(P>0.05)。结论:培美曲塞单药和联合铂类化疗方案化疗效果相当,尤其适用于非鳞癌患者,但单药化疗药物毒副作用少,因此对于晚期复发性NSCLC患者,推荐培美曲塞单药化疗方案。
Objective：To study the application value of simple pemetrexed or combined chemotherapy in the treatment of advanced recurrent non small cell lung cancer（NSCLC）.Methods：Seventy-three patients with advanced recurrent NSCLC who were admitted in our hospital from March 2012 to March 2014 were selected as the study subjects.Among them,37 patients were treated with simple pemetrexed chemotherapy（single drug group）,and 36 patients were treated with pemetrexed combined with platinum-based chemotherapy（combined group）.Results：There were no significant differences in objective remission rate and disease control rate between the single drug group（43.24%,89.19%） and the combined group（38.89%,86.11%）（P〉0.05）.Conclusion：The effects of simple pemetrexed and it combined with platinum-based chemotherapy are similar,especially suitable for patients without squamous carcinoma.The side effects of single drug chemotherapy are fewer.Therefore,for patients with advanced recurrent NSCLC,simple pemetrexed chemotherapy is recommended.
出处
《中国医药导刊》
2017年第2期168-169,175,共3页
Chinese Journal of Medicinal Guide
