摘要
目的了解该院综合性重症监护病房(ICU)患者下呼吸道标本中分离的84株鲍曼不动杆菌(ABA)的耐药情况,为临床治疗合理使用抗菌药物提供依据。方法对84株ABA进行回顾性分析,采用梅里埃VITEK2-Compact全自动微生物分析仪进行细菌鉴定及药敏试验,并采用WHONET5.6软件对其进行耐药性分析。结果 84株ABA的耐药性较强。84株ABA耐药率最高的是呋喃妥因100.00%,其次为头孢替坦98.81%和氨曲南80.95%。β-内酰胺类抗菌药物的耐药率均>75.00%,其中对亚胺培南耐药率达76.19%。各类常见的13种抗菌药物的敏感率均<30.00%。耐药细菌中的多重耐药(MDR)菌株、广泛耐药菌株和泛耐药菌株分别为67株、64株和26株,分别占79.76%、76.19%和30.95%。MDR菌株对常见的抗菌药物的非敏感率均大于90.00%。结论 ABA是常见的致病菌。实验室应加强对ICU ABA耐药菌株的分析和药敏监测,同时ICU应加强消毒隔离,避免医院感染的暴发流行。
Objective To understand the drug resistance situation of 84 strains of Acinetobacter Baumannii（ABA）isolated from the lower respiratory tract samples in ICU patients to provide a basis for the rational use of antibacterial drugs in clinic.MethodsEighty-four strains of ABA were retrospectively analyzed.The VITEK2-Compact automatic microbiological analyzer was adopted to conduct the bacterial identification and drug susceptibility test.The software Whonet5.6was used for conducting the statistical analysis.Results Eighty-four strains of ABA had strong drug-resistance.The resistance rate of nitrofurantoin was highest（100.00%）,followed by cefotetan（98.81%）and aztreonam（80.95%）.The resistance rate of beta lactam antibacterial drugs was〉75.00%,and which to imipenem was 76.19%.The sensitive rate of 13 kinds of common antibacterial drugs was 〈30.00%.MDR,XDR and PDR strains were 67 strains,64strains and 26 strains respectively,which accounted for 79.76%,76.19% and 30.95% respectively.The non-sensitivity rates of multi-drug resistant strains either to MDR or XDR was〉90.00%in non sensitive rate of common antimicrobial agents.Conclusion ABA is the major pathogen.The laboratory should strengthen the analysis and drug sensitivity monitoring of ABA resistant strains in ICU.At the same time,ICU should strengthen the disinfection and isolation to avoid the outbreak of nosocomial infections.
出处
《国际检验医学杂志》
CAS
2017年第5期649-650,653,共3页
International Journal of Laboratory Medicine
