摘要
目的:探讨miRNA-142-3p在可手术的非小细胞肺癌组织中的表达情况及其与预后的相关性。方法:回顾性分析辽宁省肿瘤医院2009年12月-2012年3月期间行手术治疗的121例非小细胞肺癌患者的临床资料。采用定量RT-PCR检测上述病例肺癌标本中miRNA-142-3p的表达水平,应用χ2检验分析miRNA-142-3p表达水平与肺癌患者各临床病理参数的相关性,应用Kaplan-Meier方法分析miRNA-142-3p表达与非小细胞肺癌生存的相关性,采用Cox风险比例模型分析预后的独立影响因素。结果:miRNA-142-3p表达量与复发转移情况相关(P<0.05),与患者性别、年龄、病理类型、分期及吸烟史无明显相关,生存分析显示miRNA-142-3p高表达组生存期明显低于低表达组(P<0.01),Cox风险比例模型分析显示miRNA-142-3p表达可作为非小细胞肺癌患者预后的独立影响因素。结论:miRNA-142-3p高表达与非小细胞肺癌复发转移相关,miRNA-142-3p高表达提示非小细胞肺癌患者预后不良。
Objective：To investigate the expression of miRNA- 142- 3p in non- small cell lung cancer and its correlation with prognosis. Methods：The clinical data of 121 cases of non- small cell lung cancer patients treated by surgery in Liaoning Province Cancer Hospital from December 2009 to March 2012 were retrospectively analyzed. The expression level of miRNA- 142- 3p in the cases of lung cancer tissues were detected by quantitative RT- PCR. The correlation of the expression of miRNA- 142- 3p with the clinical pathological parameters of NSCLC patients were analyed by χ2test. Using Kaplan- Meier method to analyze the relationship between miRNA- 142- 3p expression and survival of non- small cell lung cancer,independent factors of prognosis were analyzed by Cox proportional hazards model. Results：The expression of miRNA- 142- 3p was associated with recurrence and metastasis（ P 0. 05）,and the gender,age,pathological type,stage and smoking history were no significantly related. Survival analysis showed that high expression of miRNA- 142- 3p group survival was significantly lower than the low expression group（ P 0. 01）. Cox proportional hazard model analysis showed that the expression of miRNA- 142- 3p can be used as an independent factor of the prognosis of patients with non- small cell lung cancer. Conclusion：High expression of miRNA- 142- 3p is related to the recurrence and metastasis of non- small cell lung cancer,and the expression of miRNA- 142- 3p is associated with a poor prognosis in patients with small cell lung cancer.
出处
《现代肿瘤医学》
CAS
2017年第7期1051-1053,共3页
Journal of Modern Oncology
基金
辽宁省公益研究项目(编号:2013001019)
