摘要
目的探讨职业性慢性苯中毒的临床特点、治疗与转归。方法分析49例职业性慢性苯中毒患者中毒程度与工龄、外周血细胞计数间的关系,以及治疗前后症状、外周血细胞计数的差异。结果 49例职业性慢性苯中毒患者中37例轻度中毒,6例中度中毒,6例重度中毒。轻度组、中度组、重度组的白细胞、中性粒细胞、红细胞、血红蛋白、血小板计数均低于对照组,且差异有统计学意义(均P<0.05);轻度组、中度组与重度组间红细胞计数结果差异有统计学意义(P<0.05),轻度组与重度组间血红蛋白、血小板计数差异有统计学意义(P<0.05);患者3组间白细胞、中性粒细胞计数差异无统计学意义(P>0.05)。职业性慢性苯中毒患者经治疗后,头晕、乏力、失眠、多梦、牙龈出血、皮下瘀斑症状均有不同程度减轻;治疗前后白细胞、中性粒细胞、红细胞、血红蛋白、血小板计数差异均无统计学意义(P>0.05)。结论职业性慢性苯中毒患者红细胞、血红蛋白、血小板计数有随苯中毒轻、中、重依次递减趋势;目前治疗可缓解一般症状,但较难改善外周血白细胞、中性粒细胞、红细胞、血红蛋白等指标。
[Objective] To explore the clinical features,treatment and prognosis of occupational chronic benzene poisoning.[Methods]The relations between intoxication grade and length of work and peripheral blood cell counts,as well as the differences of symptoms,peripheral blood cell counts before and after the treatments of 49 cases of occupational chronic benzene poisoning were analyzed.[Results]49 cases of occupational chronic benzene poisoning included 37 cases of mild poisoning,6 cases of moderate poisoning,and 6 cases of severe poisoning. In the mild group,moderate group and severe group,white blood cells,neutrophils,erythrocytes,hemoglobin and platelet counts were all significantly lower than those in the control group（all P〈0.05）. The difference of erythrocytes counts was statistically significant in mild,moderate and severe group（P 〈0.05）. The differences of hemoglobin and platelet counts were statistically significant in mild and severe group（P〈0.05）.The differences of white blood cells and neutrophils counts were not statistically significant in three groups（P〉0.05）.The symptoms such as dizziness,fatigue,insomnia,dreams,bleeding gums and subcutaneous ecchymosis abated in various degrees after the treatments. The differences of white blood cells,neutrophils,erythrocytes,hemoglobin and platelet counts were not statistically significant before and after the treatments（P〉0.05）.[Conclusion]For occupational chronic benzene poisoning patients,the erythrocytes,hemoglobin and platelet counts showed a descending trend with the grade of benzene poisoning from mild,moderate to severe. The currently used treatments can relieve the general symptoms,but is difficult to improve indexes of peripheral blood leukocytes,neutrophils,erythrocytes and hemoglobin.
作者
李培茂
张艳芳
王佃鹏
张志敏
林大枫
王革非
LI Pei-mao ZHANG Yah-fang WANG Dian-peng ZHANG Zhi-min LIN Da-feng WANG Ge-fei(Department of Microbiology and Immunology, Medical College, Shantou University, Shantou Guangdong , 515031,China Department of Clinical laboratory, Shenzhen Prevention and Treatment Center for Occupational Disease, Shenzhen Guangdong, 518020 , China)
出处
《职业与健康》
CAS
2017年第1期27-29,共3页
Occupation and Health
基金
国家自然科学基金(31170852)
深圳市科技研发资金基础研究项目(JCYJ20140414110951757)
深圳市科技研发资金基础研究项目(JCYJ20160429090813380)
深圳市卫生计生系统科研项目(201402103)
关键词
苯中毒
工龄
外周血
Benzene poisoning
Length of work
Peripheral blood
