摘要
目的 探讨氟康唑漱口液氧气驱动雾化吸入治疗小儿口腔真菌感染的效果.方法选择山东省胶州人民医院小儿内科患儿60例,按随机数字表法分为对照组和试验组各30例.2组患儿均使用碳酸氢钠溶液加氟康唑胶囊.碳酸氢钠溶液5次/d,分别在晨起、三餐后、睡前含漱3 min后吐出.氟康唑胶囊每日剂量为3 mg/kg,加入0.9%氯化钠50 ml,配成1~3 mg/ml的溶液.2组不同之处在于：对照组采用传统的含漱方法,将配置好的氟康唑溶液分为5次,与碳酸氢钠溶液每2小时漱口1次,漱口结束后咽下;试验组使用氧气驱动雾化吸入疗法,与碳酸氢钠溶液间隔时间2 h,在行氧气驱动雾化吸入治疗之前,先让患儿用清水漱口,以去除口腔内的食物残渣,之后将每日剂量分为5次,分别加入雾化器内行氧气驱动雾化吸入治疗.观察2组患儿在不同部位及不同程度的口腔真菌感染愈合时间上的差异.结果2组患儿口腔黏膜炎在不同部位的愈合时间比较,试验组患儿除齿龈部位外,面颊、腭、舌、咽、唇等部位愈合时间分别为（6.67±1.68）、（6.38±1.80）、（6.36±1.96）、（6.50±1.60）、（5.00±0.82）d,均优于对照组的（8.13±2.13）、（8.00±2.14）、（8.23±2.13）、（8.67±1.75）、（7.20±1.48）d,2组比较差异有统计学意义（t=2.14~2.64,均P〈0.05）;试验组患儿Ⅰ~Ⅳ度口腔黏膜炎的愈合时间分别为（5.10±0.88）、（7.92±1.32）、（8.00±1.00）、（10.25±0.96）d,均优于对照组的（6.36±0.81）、（9.00±1.29）、（10.33±0.58）、（12.33±0.58）d,差异有统计学意义（t=2.10~3.50,均P〈0.05）.结论将氟康唑漱口液改用氧气驱动雾化吸入疗法是适合患儿口腔护理的方法,可以降低患儿口腔真菌感染的发生程度,缩短溃疡愈合时间.
Objective To explore the efficacy of fluconazole mouthwash by means of oxygen-driven atomizing inhalation for treating the pediatric oral fungal infections. Methods A total of 60 cases of child patient from the department of Pediatrics of Jiaozhou People＇s Hospital have been selected and divided into control group and test group with 30 cases for each group by the method of random number table. The sodium bicarbonate solutions as well as the fluconazole capsules were used for the two groups of children patients. Everyday there were five doses of sodium bicarbonate solution as follows：one after getting up in the morning, one after breakfast/lunch/dinner, and one before bedtime by gargling for three minutes followed by spitting. Daily dose of fluconazole capsules was 3 mg/kg, with 50 ml of NS added for preparing a solution of 1-3 mg/ml. Differences between the two groups are as follows. The control group used the traditional method of gargling. The prepared fluconazole solution was divided into five doses for gargling followed by swallowing which were carried out two hours after the sodium bicarbonate solution. The test group used the oxygen-driven atomizing inhalation therapy. The intervals with the sodium bicarbonate solution were two hours. Before the oxygen-driven atomizing inhalation therapy, the children patients had gargled with water to remove the food debris inside the mouth. Next, the daily dose was divided into five doses to be added into the nebulizers for carrying out the oxygen-driven atomizing inhalation therapy focusing on the exposed ulcer areas. The difference in healing time of oral fungal infection of different position and degree between both groups of child patient has been observed. Results The healing time of oral mucositis at different position of both groups has been compared with each other, with the exception of gingival position, the healing time of child patients in test group at the position of cheek, palate, tongue, pharynx, lips and so on was respectively （6.67±1.68） d, （6.38±1.80） d, （6.36±1.96） d, （6.50±1.60） d and （5.00±0.82） d, which were all better than that of the control group, which was （8.13 ± 2.13） d,（8.00 ± 2.14） d,（8.23 ± 2.13） d, （8.67 ± 1.75） d and （7.20 ± 1.48） d, the difference between both groups was statistically significant（t=2.14-2.64, P〈0.05）;the healing time of child patients in test group with a degree ranging from I to IV was respectively （5.10±0.88） d, （7.92±1.32） d,（8.00±1.00 ）d and （10.25±0.96）d,which were all better than that of the control group, which was（6.36±0.81）d,（9.00±1.29） d,（10.33 ± 0.58）d and（12.33 ± 0.58）d,the difference between both groups was statistically significant（t=2.10-3.50,P〈0.05）. Conclusions It＇s suitable for oral care of children patients if we replace the fluconazole mouthwash with the oxygen-driven atomizing inhalation therapy which can reduce the severity of oral mucositis and shorten the healing time.
作者
赵云
孙爱莲
何福芹
Zhao Yun Sun Ailian He Fuqin(Pediatrics Department of the Affiliated Hospital of Qingdao University, Qingdao 266300, Chin)
出处
《中国实用护理杂志》
2017年第5期362-365,共4页
Chinese Journal of Practical Nursing
关键词
氟康唑
真菌
口腔溃疡
氧气驱动雾化吸入
Fluconazole
Fungi
Oral ulcer
Oxygen-driven atomizing inhalation
