摘要
目的探讨米诺环素辅助治疗侵袭性牙周炎的疗效及对血清CRP、TNF-α和IL-17水平的影响。方法选取2014年1月1日-2015年12月31日于我院就诊的侵袭性牙周炎患者共60例,将患者随机分为两组,A组和B组患者各30例,A组患者采用米诺环素辅助治疗,B组患者仅接受洁刮治和根面平整治疗,比较两组患者的治疗效果及血清CRP、TNF-α和IL-17水平的变化状况。结果 （1）A组患者治疗有效28例,B组患者治疗有效21例,两组患者治疗总有效率差异具有统计学意义（P〈0.05）。（2）两组患者治疗前后的血清CRP、TNF-α和IL-17水平均有明显变化（P〈0.05）,但A组患者治疗后的改善状况明显优于B组患者,两者比较,差异具有统计学意义（P〈0.05）。结论临床上在对侵袭性牙周炎患者采取洁刮治和根面平整治疗后应采用米诺环素辅助治疗。
Objective To investigate the effect of minocycline on aggressive periodontitis and influence on serum CRP,TNF-alpha and IL-17 levels. Methods From January 1,2014 to December 31,2015,our hospital for treatment of aggressive periodontitis patients in 60 cases,the patients were randomly divided into two groups,A group and B group with 30 cases each. A group were treated with minocycline,B group were treated with scaling and root planning,the treatment effect of the patients in the two groups and the serum levels of CRP,TNF-alpha and IL-17 levels were compared. Results（1） A group of patients with effective treatment of 28 people,B group of patients with effective treatment of 21 people,the difference in the total effective was significant（P〈0.05）.（2） the serum levels of CRP,TNF-and IL-17 were significantly changed before and after treatment in the two groups（P〈0.05）,but the improvement of A group was significantly better than that of B group after treatment,the difference was significant（P〈0.05）. Conclusion In the clinical take scaling and root planing therapy for patients,should use aggressive periodontitis after minocycline treatment methods.
出处
《中国卫生标准管理》
2016年第36期84-85,共2页
China Health Standard Management
关键词
米诺环素
侵袭性牙周炎
疗效
Minocycline
Aggressive periodontitis
Curative effect
