摘要
目的探讨本市新生儿先天性甲状腺功能减退症（CH）的筛查情况和诊治经验。方法选择本市2008年1月至2014年12月出生的新生儿，采足跟血送指定筛查中心进行促甲状腺素（TSH）筛查，筛查结果异常者至本院进行TSH和游离甲状腺素（Err4）测定。确诊CH者给予左旋甲状腺素片规范性治疗，定期检测甲状腺功能，并进行体格评估和智能测试。结果共筛查83787名新生儿，阳性106例，确诊CH患儿68例，发病率为0．8％e。68例均予以治疗，6例失访。44例CH患儿进行体格发育随访中查骨龄均正常，达到同龄儿生长发育水平；53例CH患儿行智能发育筛查，3例可疑智能发育低下，1例异常，其余正常。结论新生儿疾病筛查是早期诊断及早期治疗CH的保障，应推广普及。确诊CH的患儿经早期规范性治疗，定期随访，其体格和智力发育可与同龄儿相当。
Objective To review the experience on screening, diagnosis and treatment for neonatal congenital hypothyroidism （ CH ） in Xuancheng City, Anhui Province. Methods From Jan 2008 to Dec 2014, peripheral blood samples from the heel were collected among 83 787 neonates and the blood samples were sent to the screening center to test the level of thyroid stimulating hormone （TSH）. Neonates with abnormal level of TSH were admitted to our hospital for further TSH and free tetraiodothyronine （ FT4 ） tests. Neonates with CH diagnosis were given standard treatments of levothyroxine and their thyroid function, physical and intelligence development were evaluated on a routine basis. Results Among the 106 neonates with abnormal TSH level , 68 were diagnosed CH. The prevalence of CH in Xuancheng City was 0. 8 %v. All 68 patients with CH received levothyroxine treatment and 6 cases were lost during follow-up. 44 patients received physical examination and their bone ages were normal. 53 patients received intelligence assessment. Only 1 of them was diagnosed of mental retardation, and 3 with suspicious mental retardation. Conclusion Neonatal screening is necessary for the early diagnosis and treatment of CH. Neonates with CH can have normal physical and mental development if they receive standard treatment as early as possible and followed up regularly.
出处
《中国新生儿科杂志》
CAS
2017年第1期27-30,共4页
Chinese Journal of Neonatology
