摘要
目的:探究乌司他丁联合阿托莫兰对感染性休克患者血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和降钙素原(PCT)水平的影响。方法:选择2013年6月~2015年12月期间我院收治感染性休克患者79例为研究对象;采用随机数字法将其分为观察组(39例)和对照组(40例),观察组患者给予乌司他丁联合阿托莫兰治疗,对照组给予常规抗感染治疗;观察并比较两组患者治疗前后IL-6、TNFα和PCT水平,比较两组患者药物不良反应、多器官功能障碍综合征(MODS)发生率及病死率。结果:治疗前两组患者间IL-6、TNF-α及PCT水平均无差异(P<0.05);治疗后两组患者IL-6、TNF-α及PCT均显著下降,且观察组IL-6、TNF-α及PCT水平低于对照组(P<0.05);治疗过程中两组患者药物不良反应发生率无差异(P>0.05);治疗后观察组MODS及死亡发生率均低于对照组(P<0.05)。结论:乌司他丁联合阿托莫兰能够改善对感染性休克患者炎症反应,降低机体IL-6、TNF-α及PCT水平,降低MODS发生率及病死率,在临床治疗感染性休克具有重要价值。
Objective： To explore the effects of ulinastatin combined with atuomolan on the levels of IL-6,TNF-α and PCT in patients with septic shock. Methods： 79 cases of septic shock in our hospital were selected as the research objects from June 2013 to December 2015,which were divided into observation group（39 cases） and control group（40 cases） by random number method; The patients in the observation group were given ulinastatin combined with reduced glutathione treatment,the patients in control group were only given conventional anti-infection treatment; To observe and compare the levels of IL-6,TNF- α and PCT before and after treatment in both groups;To compare the incidence of adverse drug reactions,multiple organ dysfunction syndrome（MODS） and mortality between two groups after treatment. Results： There were no differences in the levels of IL-6,TNF-α and PCT between two groups before treatment（P〈0.05）; The levels of IL-6,TNF-α and PCT were significantly decreased after treatment; and the levels of IL-6,TNF-α and PCT in observation group were lower than that of control group（P〈0.05）; There was no difference in the incidence of adverse drug reactions between two groups in the course of treatment（P〉0.05）; The incidence of MODS and mortality in the observation group were lower than those in the control group after treatment（P〈0.05）. Conclusion： Ulinastatin combined with atuomolan can improve the inflammatory response in patients with septic shock; To reduce the levels of IL-6,TNF-α and PCT,and to reduce the incidence and mortality of MODS,which has great value in clinical treatment of septic shock.
出处
《现代生物医学进展》
CAS
2017年第3期496-499,共4页
Progress in Modern Biomedicine
基金
广州市医药卫生科技项目(20151A011095)
