摘要
目的:观察和评价外配式耳甲迷走神经刺激仪治疗原发性失眠及其情感障碍的临床疗效。方法:对35例失眠兼情感障碍患者,于耳甲迷走神经分布区使用外配式耳迷走神经刺激仪(TENS-200A型)治疗,每次30min,每日2次,每周5d,持续治疗4周,第6周周末进行随访。采用匹兹堡睡眠质量指数(PSQI)、17项汉密顿抑郁量表(17HAMD)和汉密顿焦虑量表(HAMA)进行评价,观察患者治疗前后的PSQI、17HAMD和HAMA评分,并进行安全性观察。结果:患者PSQI评分在治疗第2周周末为(13.20±3.61)分,较治疗前降低,差异有统计学意义(P<0.05);患者治疗第4周末及第6周周末随访时17HAMD和HAMA评分较治疗前均有不同程度下降,差异有统计学意义(均P<0.05)。未观察到不良反应的发生。结论:外配式耳甲迷走神经刺激仪可缓解原发性失眠症状,同时又可改善患者的焦虑、抑郁症状,具有一定远期疗效,且较为安全。
Objective To observe and evaluate the clinical efficacy of transcutaneous vagus nerve stimulation（taVNS）at auricular concha for primary insomnia（PI）and affective disorder.Methods A total of 35 patients who met the diagnosis standard of PI in Diagnostic and statistical manual of mental disorders（5th edition）were included.The self-developed auricular vagus nerve stimulator（TENS-200A）was applied at auricular concha,30 min per treatment,twice a day,5days a week for consecutive 4weeks.The follow-up visit was conducted at the end of 6th week.The Pittsburg sleep quality index scale（PSQI）,17-items Hamilton depression scale（17HAMD）and Hamilton anxiety scale（HAMA）were applied for evaluation.The PSQI,HAMA and 17 HAMD were observed before and after treatment;the safety was also observed.Results Compared before treatment,the PSQI was significantly decreased to（13.20±3.61）at the end of 2nd week（P〈0.05）;compared before treatment,the 17 HAMD and HAMA were significantly decreased at the end of 4th week and 6th week（all P〈0.05）.No adverse reaction was observed.Conclusion The taVNS could not only relieve PI symptoms,but also improve the depressive and anxiety symptoms,in addition,it may have positive long-term efficacy and safety.
出处
《中国针灸》
CAS
CSCD
北大核心
2017年第3期269-273,共5页
Chinese Acupuncture & Moxibustion
基金
国家自然科学基金资助项目:81473780,81674072
国家重大研发计划资助项目:Z161100002616003
国家科技支撑计划资助项目:2012BAF14B10
关键词
失眠
情感障碍
耳穴
耳迷走神经
仪器
primary insomnia（PI）
affective disorder
auricular point
auricular vagus nerve
apparatus
