摘要
本文主要研究桑黄纤孔菌子实体粉的毒理学并评价其安全性。利用小鼠急性毒性试验和遗传毒性试验(Ames试验、小鼠骨髓细胞微核试验、小鼠精子畸形试验)对桑黄纤孔菌子实体粉的毒性进行考察。试验结果显示,小鼠对桑黄纤孔菌子实体粉最大耐受量大于12g/kg;桑黄纤孔菌子实体粉在有或无S9的条件下,对组氨酸营养缺陷型鼠伤寒沙门氏菌TA97a、TA98、TA100及TA102均无潜在致突变性;桑黄纤孔菌子实体粉在小鼠骨髓细胞微核试验和小鼠精子畸形试验中均呈阴性反应,不同剂量的样品组与阴性对照组之间无显著性差异。该结果表明桑黄纤孔菌子实体粉基本无毒性,属实际无毒物质。本研究为桑黄纤孔菌子实体粉的产品开发和应用提供了科学依据。
The toxicology and security of fruiting body of Inonotus songhuang was evaluated by investigating acute toxicity test and genetic toxicity test （Ames test, micronucleus test of bone marrow cell, sperm shape abnormality test） in mice. The results showed that the maximum tolerance dosage of fruiting body powder of Inonotus sanghuang for mice was more than 12.5g/kg. Under the conditions with or without $9, fruiting body powder of Inonotus sanghuang demonstrated no potential mutagenicity on Salmonella typhimurium TA97a, TA98, TA100 and TAI02. Micronucleus test of bone marrow cell and sperm shape abnormality test in mice exhibited negative reaction and there were no significant differences between different doses of treated groups and negative control, indicating that fruiting body powder of Inonotus sanghuang is non-toxic. This study provides a scientific basis for product development and application of fruiting body powder of Inonotus sanghuang
出处
《菌物学报》
CAS
CSCD
北大核心
2017年第3期376-384,共9页
Mycosystema
基金
十二五国家科技支撑计划课题(2012BAD36B05)~~
关键词
桑黄菌
子实体粉
急性毒性
遗传毒性
Inonotus sanghuang, fruiting body powder, acute toxicity, genetic toxicity
