摘要
目的:观察米诺环素治疗急性逆行性牙髓炎(ARP)的临床疗效、安全性及对患者疼痛症状的影响。方法:选择2015年1-10月青岛农业大学校医院和青岛大学医学院附属医院收治的ARP患者100例(100颗),按随机数字表法分为观察组和对照组,各50例(50颗)。对照组患者给予甲醛甲酚溶液根管封药治疗,观察组患者给予盐酸米诺环素软膏根管封药治疗。两组患者均3 d后复诊,随访5个月后评价疗效;观察治疗前及治疗后3 d疼痛症状评分及白细胞介素-2(IL-2)及肿瘤坏死因子α(TNF-α)水平并记录两组患者不良反应发生情况。结果:观察组患者临床总有效率为98.00%,显著高于对照组的86.00%,差异有统计学意义(P<0.05)。治疗前,两组患者叩痛评分、松动度评分、IL-2、TNF-α比较,差异均无统计学意义(P>0.05);治疗3 d后,两组患者叩痛评分、松动度评分、IL-2、TNF-α水平均显著降低,且观察组显著低于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:米诺环素治疗ARP疗效显著,能有效改善患者的疼痛症状,且安全性较好。
OBJECTIVE： To observe clinical efficacy and safety of minocycline for acute retrograde pulpitis （ARP） and its effects on pain. METHODS： One hundred （100 teeth） ARP patients in Hospital of Qingdao Agriculture University and the Affiliated Hospital of Medical College during Jan.-Oct. in 2015 were divided into observation group and control group according to random number table, with 50 cases in each group （50 teeth）. Control group was given root canal therapy of Formaldehyde cresol formocresol solution; observation group was given was given root canal therapy of Minocycline hydrochloride cream. Both groups were rechecked 3 days later, and therapeutic efficacy was evaluated after 5 month follow-up; pain score, IL-2 and TNF-α levels were observed before and 3 d after treatment, and the occurrence of ADR was recorded in 2 groups. RESULTS： The total response rate of observation group was 98.00%, which was significantly higher than 86.00% of control group, with statistical significance （P〈 0.05）. There was no statistical significance in percussion pain score, mobility score, IL-2 and TNF-α levels between 2 groups before treatment （P〉0.05）. Three days after treatment, percussion pain score, mobility score, IL-2 and TNF-α levels of 2 groups were significantly decreased; the observation group was significantly lower than the control group, with statistical significance （P〈 0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P〉0.05）. CONCLUSIONS： Minocycline shows significantly therapeutic efficacy for ARP, and can effectively improve pain symptoms with good safety.
出处
《中国药房》
CAS
北大核心
2017年第8期1111-1113,共3页
China Pharmacy
