摘要
目的探讨2型糖尿病(T2DM)患者血清分泌型卷曲相关蛋白5(SFRP-5)水平与糖尿病肾病(DN)的相关性。方法选择T2DM住院患者137例,根据尿白蛋白排泄率(UAER)分为3组:正常白蛋白尿组(A组)47例;微量白蛋白尿组(B组)45例;大量白蛋白尿组(C组)45例。选择50例健康体检者作为对照组。ELISA法检测血清SFRP-5,同时测定空腹静脉血糖(FBG)、血脂、肝肾功能、UAER。比较各组间的指标差异。结果 4组SFRP-5比较差异均有统计学意义(P<0.05)。T2DM患者血清SFRP-5的水平低于对照组,B组、C组血清SFRP-5水平高于A组,C组血清SFRP-5水平高于B组(均P<0.05)。血清SFRP-5水平与舒张压(DBP)、总胆固醇(CHO)、甘油三酯(TG)、FBG、空腹血清胰岛素(Fins)、胰岛素抵抗指数(HOMA-IR)、尿素氮(BUN)、肌酐(CR)、UAER呈正相关,与高密度脂蛋白(HDL)、肾小球滤过率(GFR)、总胆红素呈负相关。多元线性回归分析显示,UAER、HOMA-IR、空腹血糖(FBG)、空腹血糖(FBG)、尿酸(UA)、收缩压(SBP)、TG是SFRP-5的独立影响因素。结论T2DM患者血清SFRP-5水平随着UAER的增加而升高,两者可能参与糖尿病肾病的发生,并可能成为糖尿病肾病发生及发展过程中的新的标记物。
Objective To investigate relationship between serum secreted frizzled-related protein 5（SFRP-5）and diabetic nephropathy.Methods A total of 137 patients with type 2diabetes mellitus were enrolled.According to urinary albumin excretion rate,all patients with type 2diabetes mellitus were divided into three groups：normal albuminuria group（group A,n =47）,microalbuminuria group（group B,n =45）and macroalbuminuria group（group C,n =45）.The control group included 50 healthy individuals.Serum SFRP-5was determinated with ELISA method.Fasting venous blood samples were collected for glucose and lipid.Twenty-four hour urine was also collected for UAER.Differences of indexes were compared between groups.Results The level of serum SFRP-5between groups was statistically significant（P〈0.05）;The level of serum SFRP-5in T2 DM group was significantly lower than that of the normal control group（P〈0.05）;The levels of serum SFRP-5in the microalbuminuria group and macroalbuminruia group were significantly higher than that of normal albuminuria group（P〈0.05）,and the level of serum SFRP-5in the macroalbuminuria group was significantly higher than that of the microalbuminuria group（P〈0.05）.Correlation analysis showed that the levels of SFRP-5were positively correlated with DBP,CHO,TG,FBG,Fins,HOMA-IR,BUN,CR and UAER,and negatively correlated with HDL,eGFR and total bilirubin.Multiple linear regression analysis showed that the levels of UAER,HOMA-IR,FBG,UA,SBP and TG were independent influencing factors for SFRP-5.Conclusion Serum SFRP-5gradually increases as the urinary albumin excretion rate becomes higher in patients with type 2diabetes mellitus,both may be involved in the occurrence and development of diabetic nephropathy（DN）,and may Serum SFRP-5become a new marker of diabetic nephropathy.
作者
许娜
郭淑芹
张云良
马竞轩
王翯
白广芹
提素芳
黄一茜
杜亚涛
Xu Naa Guo Shuqina Zhang Yunlianga Ma Jingxuana Wang Hea Bai Guangqina Ti Sufanga Huang Yiqiann Du Yataoc(a. Department of Endocrinolog b. Department of Physical Examinatio c. Department of Laboratory Medicine, Baoding No. 1 Central Hospital ,Baoding 071000, Chin)
出处
《临床荟萃》
CAS
2017年第3期233-236,共4页
Clinical Focus
关键词
糖尿病
2型
糖尿病肾病
分泌型卷曲相关蛋白5
secreted frizzled-related protein 5
type 2diabetes mellitus
diabetic nephropathy
