摘要
目的对比腹腔镜手术与开腹手术对结直肠癌患者的疗效及安全性。方法选取了361例结直肠癌患者,按随机数字表法分为2组。观察组(180例)行腹腔镜切除,对照组(181例)行传统开腹手术治疗。观察并记录患者近远期疗效、围手术期血清白细胞介素-6(IL-6)和白细胞介素-6(IL-8)水平、及随访3年期间并发症发生情况,以评价腹腔镜手术与开腹手术对结直肠癌患者的疗效及安全性。结果 2组在下床时间、排气时间、进半流食时间、排便时间上相比,差异没有统计学意义(P>0.05);观察组患者住院时间明显短于对照组(P<0.05)。随访3年期间,2组在局部复发率、远处转移率及2年、3年生存率上相比,差异没有统计学意义(P>0.05)。术后1 d,3 d 2组患者血清IL-6和IL-8水平均明显升高,但观察组患者血清IL-6和IL-8水平明显低于对照组。随访3年期间,观察组并发症共计11例,对照组19例,差异没有统计学意义(P>0.05)。结论采用腹腔镜手术治疗结直肠癌,近远期疗效与开腹手术相当,能减轻手术创伤引起的炎症反应,术后并发症少,手术安全性较传统开腹手术高,值得临床推广使用。
Objective To study the efficacy and safety of laparoscopic surgery and open surgery in the treatment of colo -rectal cancer .Methods 361 patients with colorectal cancer were divided into 2 groups according to odd-even number of hospital-ization.The efficacy and safety of laparoscopic surgery and open surgery in the treatment of colorectal cancer were evaluated by long-term and short-term efficacy,IL-6 and IL-8 level during perioperative period and complications during 3-year follow-up.Re-sults There were no statistical significance in recovery time ,exhaust time,semi liquid diet time,defecation time between the 2 groups（P〉0.05）.The hospitalization of the observation group was shorter than that of the control group （P〈0.05）.During 3 years follow-up,there were no statistical significance in recurrence rate ,metastasis rate,2-and 3-years survival rates between the 2 groups.1 d and 3 d after surgery,the IL-6 and IL-8 level of serum significantly increased （P〈0.05）.During 3-year follow-up, there were no statistical significance in complications between the 2 groups（P〉0.05）.Conclusion Laparoscopic surgery for colorectal cancer has similar short-term and long-term efficacy as the open surgery .It can lighten the inflammation caused by sur-gical trauma and reduce the complications .The safety of laparoscopic surgery is higher than that of the open surgery .It is worthy of clinical use .
出处
《实用癌症杂志》
2017年第3期418-420,424,共4页
The Practical Journal of Cancer
