摘要
目的:探讨纤维蛋白胶(fibrin glue,FG)在全膝关节置换术(total knee arthroplasty,TKA)中应用的有效性和安全性。方法:通过检索Pub Med、Embase、Cochrane Library、CNKI、CBM、万方等数据库,同时手工检索图书馆馆藏期刊,由2位研究者按照纳入和排除标准独立筛选高质量的随机对照试验(randomized controlled trials,RCTs)文献,采用Rev Man 5.2软件对提取的数据进行统计学分析。结果:共纳入11个RCTs,共973个TKA患者。Meta分析结果显示:与对照组相比,纤维蛋白胶可以减少TKA术后引流(MD=-227.36,95%CI=-359.47^-95.25,P=0.001);血红蛋白丢失量(MD=-0.63,95%CI=-0.79^-0.46,P=0.000);总失血量(MD=-235.59,95%CI=-453.31^-17.86,P=0.030);输血率(OR=0.44,95%CI=0.31~0.61,P=0.000);且不增加术后并发症的发生(OR=0.94,95%CI=0.61~1.45,P=0.790)。结论:FG可以有效减少TKA术后引流量,总失血量,血红蛋白丢失量,输血率但不增加术后并发症的发生。
Objective：To evaluate the efficacy and safety of fibrin glue in total knee arthroplasty（TKA）. Methods：Studies were searched from Pub Med,Embase,Cochrane Library,CNKI,CBM,Wanfang digital journals and other internet databases. Two independent reviewers searched and assessed high-quality RCTs. The relevant data were analyzed using Rev Man 5.2 software. Results：Eleven studies including a total of 973 patients were included in the analysis. Compared with those in the control group,fibrin glue achieved a decrease in drain volume（MD=-227.36,95%CI=-359.47 to-95.25,P=0.001）,hemoglobin reduction（MD=-0.63,95%CI=-0.79 to-0.46,P=0.000）,transfusion rate（OR=0.44,95%CI=0.31 to 0.61,P=0.000）,total blood loss（MD=-235.59,95%CI=-453.31 to-17.86,P=0.03）,and did not increase the incidence of complications（OR=0.94,95%CI=0.61 to 1.45,P=0.790）. Conclusion：Fibrin glue is effective in TKA without increasing the risk of complications.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2017年第2期158-162,共5页
Journal of Chongqing Medical University
基金
国家自然科学基金资助项目(编号:81160225
81260453
81360451)
新疆兵团医药卫生专项资助项目(编号:2013BA020)
兵团国际交流与合作专项基金资助项目(编号:2012BC002
2011BC004)
兵团科技创新团队专项基金资助项目(编号:2014CC002)
