摘要
细胞应对细菌或病毒感染及来自环境的各种化学药物时常表现为在细胞质内形成大量空泡，其中有些空泡来源于内体和溶酶体，称为内体和溶酶体的空泡化。空泡的形成过程及分子机制复杂，有些细胞形成空泡时还伴随着细胞死亡，但空泡化与细胞死亡的关系仍不明确。因而对内体和溶酶体空泡化进行研究，以便更好地理解细胞对外源刺激的应激反应及其分子机制。
Cells respond to bacterial or viral infection and the stimuli of chemical agents from the envi- ronment in various ways. In certain circumstances, cells form massive cytoplasmic vacuoles ,termed cytoplasmic vacuolization. Cytoplasmic vacuoles originated from endosomes or lysosome, designated in this review as the en- do-lysosomal vacuoles, have been observed in mammalian cells exposing to various stimuli such as bacteria, viru- ses ,and low-molecular-weight chemical compounds. Endo-lysosomal vacuolization sometimes accompanies cell death, but the molecular mechanism of vacuolization and its interaction with cell death remain unclear. Here we review the research progress about endo-lysosomal vacuolization in order to have a better insight into the molecu- lar mechanisms and its effect on the interaction between the cell and its environment.
作者
赵子越
赵文然
Zhao Ziyae Zhao Wenran(Department of Cell Biology, Harbin Medical University, Harbin 150081, China)
出处
《国际免疫学杂志》
CAS
2017年第1期78-83,共6页
International Journal of Immunology
基金
基金项目：国家自然基金课题（81672007）
关键词
内体
溶酶体
胞质空泡
Endosome
Lysosome
Cytoplasmic vacuolization
