摘要
药物引发的安全性问题一直受到各国药品管理部门广泛而高度的重视,药物安全性评价技术和方法更是各国学者研究的热点。近年来,随着科学技术的不断发展,新的安全性评价技术和方法不断出现,包括肝脏、肾脏、心脏等靶器官毒性,发育和生殖毒性,遗传毒性和致癌性等方面的评价技术和方法。本文主要结合本中心近10年来的研究成果,对药物安全性评价新技术和新方法的研究进展进行了综述。
The safety problems caused by drugs are widely and highly paid attention by the drug administration departments of various countries. The technology and method for drug safety evaluation is also a research focus of scholars in the world. In recent years, with the development of science and technology, new techniques and methods for drug safety evaluation are developed, including evaluation techniques and methods of liver, kidney, heart and other target organ toxicity, developmental and reproductive toxicity, genetic toxicity and carcinogenicity. In this paper, combined with the research results of our laboratory in the past ten years, the research advances of new techniques and methods for drug safety evaluation are reviewed.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2017年第3期341-350,共10页
Chinese Journal of Pharmaceuticals
基金
上海市研发公共服务平台项目(15DZ2290300)
关键词
药物安全性
靶器官毒性
发育和生殖毒性
遗传毒性
致癌性
新型品种
drug safety
target organ toxicity
developmental and reproductive toxicity
genetic toxicity
carcinogenicity
new drug variety
