摘要
(1)目的比较利伐沙班、低分子肝素钠预防膝关节交叉韧带重建术后深静脉血栓(Deep Vein Thrombosis,DVT)形成的疗效和安全性。(2)方法选取2014年7月~2016年8月收治的80例行手术治疗的膝关节交叉韧带损伤患者为研究对象,其中男49例,女31例;年龄19~62岁,平均(34.8±10.2)岁。按照随机原则分为利伐沙班组和低分子肝素钠组,各40例。两种药物均按照用药规范进行抗凝治疗。于术前及术后两周行下肢彩色多普勒超声检查,观察深静脉血栓及其他出血事件发生情况,并检测术前、术后活化部分凝血活酶时间(Activated Partial Thromboplastin Time,APTT)、凝血酶原时间(Prothrombin Time,PT)、血小板(Platelet,PLT)等各项指标。(3)结果利伐沙班组DVT发生率为2.5%(1/40),低分子肝素钠组为17.5%(7/40),两组间比较差异有统计学意义(χ2=5.000,P<0.05);两组患者术后APTT、PT、PLT差异均无统计学意义(P>0.05)。(4)结论利伐沙班对于预防膝关节交叉韧带重建术后下肢DVT的有效性和安全性优于低分子肝素钠。
Objective To compare the efficacy and safety of rivaroxaban and low molecular weight heparin sodium（LMWHS） for deep vein thrombosis（DVT）in patients with reconstruction of cruciate ligament of knee joint.Methods A total of 80 patients with cruciate ligament injured of knee joint hospitalized and treated by operation from July 2014 to August 2016 were selected as research subjects,among whom 49 males and 31 females with a mean age of（34.8±10.2）years old（19±62 years）.All patients were randomly divided into two groups,40 in each group.Two drugs were given to patients according to the present guidelines.Color Doppler ultrasound was used to identify DVT before operation and after two weeks, the occurrence of other bleeding events were also recorded. Activated partial thromboplastin time（APTT）.prothrombin time（PT）.platelet（PLT）were tested respectively on preoperation and after surgery. Results DVT incidence in rivaroxaban group（2.5 %, 1/40）was lower than that in LMWHS group （ 17.5 ±, 7/40） with significant difference （Х^2 = 5. 000, P 〈 0.05）. The two drugs also showed no significant difference in APTT, PT and PLT after surgy（P〉0.05）. Conclusion Rivaroxaban can reduce the incidence of DVT without increasing bleeding in patients with reconstruction of cruciate ligament of knee joint.
出处
《华北理工大学学报（医学版）》
2017年第2期123-126,共4页
Journal of North China University of Science and Technology：Health Sciences Edition
关键词
深静脉血栓
利伐沙班
低分子肝素钠
交叉韧带
重建
Deep vein thrombosis.Rivaroxaban.Low molecular weight heparin sodium.Cruciate ligament. Reconstruction
