摘要
目的建立本地区健康妊娠妇女妊娠各阶段甲状腺功能指标的参考范围,探讨各指标的变化规律及临床意义。方法采用化学发光免疫分析方法测定健康妊娠妇女和非妊娠妇女血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)和游离甲状腺素(FT4),采用双侧限值P2.5-P97.5建立健康非妊娠妇女和妊娠各期特异的血清TSH、FT3和FT4的参考范围。结果健康非妊娠妇女、妊娠早期、中期和晚期的TSH参考范围分别为:1.15-4.58mIU/L,0.44-3.34mIU/L,0.53-4.01mIU/L,0.95-4.28mIU/L;FT3参考范围分别为3.98-6.18pmol/L,3.69-5.95pmol/L,3.52-5.43pmol/L,3.30-5.05pmol/L;FT4参考范围分别为:12.86-20.32pmol/L,12.01-19.43pmol/L,9.28-17.71pmol/L,8.57-16.06pmol/L。按照此参考范围标准,妊娠各期甲状腺功能异常总检出率为7.8%。结论健康非妊娠妇女和妊娠各期妇女的甲状腺功能指标参考范围各不相同,建立适合本地区的健康妇女妊娠各期甲状腺功能指标参考范围对预防和治疗妊娠期甲状腺功能异常疾病具有重要意义。
Objective To establish the reference ranges of thyroid functional parameter in different stages of the pregnant women,and study the change and clinical significance of those parameter.Methods The thyroid stimulating hormone（TSH）,serum free Triiodothyronine（FT3）and serum free thyroid（FT4）levels in healthy pregnant women and non-pregnant women were determined by chemiluminescence immunoassay method,double-side limiting value（P2.5and P97.5）were used to express the reference ranges of TSH,FT3 and FT4.Results The reference ranges of TSH in healthy non-pregnant women,first trimester of pregnancy,second trimester of pregnancy and third trimester of pregnancy were：1.15-4.58 mIU/L,0.44-3.34 mIU/L,0.53-4.01 mIU/L and 0.95-4.28 mIU/L;FT3：3.98-6.18pmol/L,3.69-5.95pmol/L,3.52-5.43pmol/L and 3.30-5.05pmol/L;FT4：12.86-20.32pmol/L,12.01-19.43pmol/L,9.28-17.71pmol/L and 8.57-16.06pmol/L.According to the standard,the prevalence of thyroid dysfunction was7.8%.Conclusion The reference ranges of thyroid functional parameter in healthy non-pregnant women and different stages of the pregnant women were different,it was very important to establish the reference ranges of thyroid functional parameter in different stages of the pregnant women for preventing and treating the thyroid dysfunction.
出处
《中国实验诊断学》
2017年第3期461-464,共4页
Chinese Journal of Laboratory Diagnosis
关键词
妊娠
甲状腺素
参考范围
Pregnancy
Thyroxine
Reference range
