摘要
目的探讨翼状胬肉切除术与自体角膜缘干细胞移植术联合治疗翼状胬肉的疗效。方法选取2014年8月至2016年2月在我院被诊断为翼状胬肉的患者80例,根据自愿原则随机将其分为观察组40例和对照组40例,观察组患者采用翼状胬肉切除术与自体角膜缘干细胞移植术联合治疗,对照组患者单纯采用翼状胬肉切除术治疗,通过观察记录两组患者治疗后的总有效率、不良反应发生率及伤口愈合时间,评价翼状胬肉切除术与自体角膜缘干细胞移植术联合治疗翼状胬肉的疗效。结果观察组患者治疗后的总有效率为95.0%,对照组患者治疗后的总有效率为75.0%,组间差异有统计学意义(P<0.05)。观察组患者复发6例,复发率为15.0%,不良反应4例,不良反应发生率为10.0%,伤口愈合时间为(6.4±1.2)d;对照组患者复发15例,复发率为37.5%,不良反应12例,不良反应发生率为30.0%,伤口愈合时间为(9.2±1.5)d,组间差异具有统计学意义(P<0.05)。结论对于翼状胬肉患者而言,采用翼状胬肉切除术与自体角膜缘干细胞移植术治疗效果明显高于单纯使用翼状胬肉切除术,临床治疗效果显著,值得推广。
Objective To discuss the curative effect of pterygium excision combined with autologous corneal limbal stem cell transplantation in the treatment of pterygium. Methods Eighty patients with pterygium were selected and randomly divided into observation group and control group, with 40 cases in each group. The observation group was treated with pterygium excision combined with autologous corneal limbal stem cell transplantation and the control group only received pterygium excision treatment. The efficacy of pterygium excision combined with autologous corneal limbal stem cell transplantation in the treatment of pterygium was evaluated with total effective rate, adverse reaction and wound healing time. Results The total effective rate of the observation group after treatment was 95.0%, while the control group with the total effective rate was 75.0%, the difference between the two groups had statistical significance （P〈0.05）. Six patients in the observation group relapsed, the recurrence rate was 15.0%, 4 cases had the adverse reaction, adverse reactions incidence rate was 10.0%, the wound healing time of the observation group was （6.4±1.2） d; 15 patients in the control group relapsed, the recurrence rate was 37.5%, 12 cases had the adverse reaction, the recurrence rate was 30.0%, the wound healing time of the control group was （9.2±1.5） d, the differcences were statistically significant （P〈0.05）. Conclusion Pterygium excision surgery and autologous corneal limbal stem cell transplantation in the treatment of pterygium patient has significant better effect, which is worthy of promotion.
出处
《临床医学研究与实践》
2017年第7期67-68,共2页
Clinical Research and Practice
关键词
翼状胬肉切除术
自体角膜缘干细胞移植术
联合治疗
pterygium excision
autologous corneal limbal stem cell transplantation
combined treatment
