摘要
目的研究益生菌联合三联疗法治疗Hp阳性消化性溃疡的疗效,同时配合心理、用药、饮食等护理干预及指导。方法将100例确诊的消化性溃疡患者随机分为两组,每组50例,其中对照组采取雷贝拉唑、克拉霉素、阿莫西林三联疗法,研究组同时联合益生菌进行治疗,同时研究组配合给予心理、用药、饮食等护理干预及指导,并进行用健康教育干预,尤其侧重进行心理干预。结果研究组患者治疗后的总有效率为92%,显著高于对照组患者治疗后的78%,组间比较差异具有显著性(P<0.05)。研究组的腹痛、恶心呕吐、反酸暖气及消化道出血的发生率显著低于对照组,组间比较差异具有显著性(P<0.05)。研究组的Hp根除率为92%(46/50),显著高于对照组的Hp根除率76%(38/50),组间比较差异具有显著性(P<0.05)。研究组患者治疗后的生活质量评分显著高于对照组,组间比较差异具有显著性(P<0.05)。研究组的依从率为96%(48/50),显著高于对照组的依从率78%(39/50),组间比较差异具有显著性(P<0.05)。结论益生菌联合三联疗法治疗Hp阳性消化性溃疡疗效确切,同时配合有效的护理干预,能明显缓解患者的临床症状,提高Hp根除率,使患者积极配合治疗,从而提高疗效,改善患者的生活质量,值得推广和应用。
Objective To study the curative effect of probiotics combined with triple therapy in the treatment of Hp positive peptic ulcer, at the same time combined with psychological intervention, medication, diet and other nursing intervention and guidance. Methods 100 patients with peptic ulcer were randomly divided into two groups, with 50 patients in each group. The control group was given the triple therapy of rabeprazole, clarithromycin and amoxicillin. The study group was further given probiotics for the treatment. At the same time, the study group was given psychological, medication, diet and other nursing intervention and guidance. And health education intervention was carried out, with a particular emphasis on psychological intervention. Results The total effective rate in the study group was 92% after the treatment, which was significantly higher than that in the control group（78%）. The difference between the two groups was significant （/9〈0.05）. The incidence rates of abdominal pain, nausea, vomiting, acid reflux and belching, and gastroin- testinal bleeding in the study group were significantly lower than those in the control group, and the differences be- tween groups were significant （P〈0.05）. The eradication rate of Hp in the study group was 92% （46/50）, which was sig nificantly higher than that in the control group（76%, 38/50）. The difference between groups was. significant（P〈0.05）. The quality of life scores of the patients in the study group were significantly higher than those in the control group, and the difference between groups was significant （P〈0.05）. The compliance rate in the study group was 96% （48/50）, which was significantly higher than that in the control group（78%, 39/50）. There was significant difference between the two groups （P〈0.05）. Conclusion Probiotics combined with triple therapy in the treatment of Hp positive peptic ulcer is ef fective. Combined with effective nursing intervention, it can significantly relieve the clinical symptoms of patients, and improve Hp eradication rate, so that the patients can actively cooperate with the treatment, thereby enhancing the effi- cacy and improving the quality of life of patients, which is worthy of promotion and application.
出处
《中国现代医生》
2017年第3期153-156,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2015KYB352)
