摘要
目的探讨奥氮平对儿童精神分裂症(COS)患者糖脂代谢、肝功能及泌乳素水平的影响,为临床用药提供参考。方法选取38例COS患者(13~17岁)进行为期至少2周的奥氮平治疗,比较治疗前、后患者的体质量、丙氨酸氨基转氨酶(ALT)、天门冬酸氨基转氨酶(AST)、总胆固醇(TC)、三酰甘油(TG)、血糖(GLU)、泌乳素(PRL)的变化。结果服药治疗后患儿的体质量明显增加,平均增加(3.50±1.90)kg(P<0.01)。治疗后患儿的ALT、AST、TC、TG、PRL均高于治疗前(P<0.05)。但是治疗前、后血糖比较差异无统计学意义(P=0.598)。治疗前后体质量的变化与ALT、AST水平呈正相关(r=0.366、0.377,P<0.05);而治疗前、后患儿的PRL与体质量的改变则呈负相关(r=-0.432,P<0.01)。结论奥氮平可以导致COS患者的体质量增加,ALT、AST、TC、TG、PRL水平升高。
Objective To study the effects of olanzapine on glucolipid metabolism,liver function and prolactin level in childhood onset schizophrenia（COS）to provide reference for clinical medication.Methods Thirty-eight patients with COS aged 13-17 years old were treated with olanzapine for at least two weeks.The changes of body mass,alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,total cholesterol（TC）,triglyceride（TG）,glucose（GLU）and prolactin（PRL）were detected and compared between before and after treatment.Results The body mass after medication in children patients was significantly increased,average increase by（3.50±1.90）kg（P〈0.01）.The levels of ALT,AST,TC,TG and PRL after treatment were higher than before treatment（P〈0.05）.However,there was no statistically significant difference in blood GLU level between before and after treatment（P=0.598）.The body mass change before and after treatment was positively correlated with ALT and AST levels（r=0.366,0.377,P〈0.05）;whereas the PRL level before and after treatment was negatively correlated with the body mass change（r=-0.432,P〈0.01）.Conclusion Olanzapine can lead to the body weight gain and increase of ALT,AST,TC,TG and PRL levels in COS patients.
作者
刘克锋
田鑫
薛文华
赵杰
Liu Kefeng Tian Xin Xue Wenhua Zhao Jie(Department of Pharmacy, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Chin)
出处
《重庆医学》
CAS
北大核心
2017年第9期1193-1195,共3页
Chongqing medicine
关键词
奥氮平
精神分裂症
儿童
糖脂代谢
肝功能
泌乳素
olanzapine
schizophrenia
childhood
glucolipid metabolism
liver function
prolactin
