摘要
目的探讨柔红霉素(DNR)治疗小儿急性白血病所致心脏毒性。方法回顾性分析2010年3月~2016年6月在潍坊市人民医院小儿内科就诊的102例应用DNR治疗的急性白血病患儿的临床资料,其中13例发生心脏毒性,按DNR累积量进行分组分析;并对其临床资料进行对比研究。结果 DNR累积量越大,心脏毒性越易发生,且肝功受损会增加其发生率。结论定期心脏检查,监测生化指标,及早发现DNR心脏毒性,以控制药物剂量,减少心脏损害。
Objective To investigate the daunomycin-induced（DNR） cardiotoxicity in the treatment of pediatric aeure leukemi- a. Methods Retrospective analysis of clinical data of 102 patients with acute leukemia treated by DNR in the department of pediatrics,weifang people＇s hospilal from March 2010 to June 2016,cardiac toxicity was occurred in 13 eases,according to the cumulative amount of DNR. And the clinical data were compared and studied. Results Thirteen cases showed cardiotoxicity. The greater the DNR accumulation,the more cardiac toxieitv occurs. And the hepatic lesion could increase the incidence of cardiotoxicity. Conclusion It is necessary to routine cardiac markers or monitor bioehenlical indicator to check for early detection of eardiotoxicity. Controlling dose is needed to prevent cardiotoxicitv.
出处
《潍坊医学院学报》
2017年第1期45-46,共2页
Acta Academiae Medicinae Weifang
