摘要
目的检测血清总胆汁酸(TBA)水平,探讨血清总胆汁酸测定在足月新生儿黄疸诊治中的临床意义。方法选取82例临床资料完整,诊断为新生儿黄疸的患儿为研究对象,分为重度黄疸组(A组)、轻度黄疸组(B组)、生理黄疸组(C组),检测各组患儿血清中总胆汁酸(TBA)的水平及其他肝功能相关指标并进行比较。结果 1A组及B组TBA、TBTL(总胆红素)、DBTL(直接胆红素)、ALT(丙氨酸转氨酶)水平显著高于C组,差异有统计学意义(P<0.05);B组与C组GGT(γ-谷氨酰转肽酶)水平比较差异无统计学意义(P>0.05)。2A,B两组TBA水平与TBTL,DBTL,GGT,ALT各项肝功能指标有直线相关关系。3A,B组治疗前TBA,TBTL水平较治疗后明显下降,差异有统计学意义(P<0.05),但A组TBA及TBIL消退时间较B组长,差异有统计学意义(P<0.05)。结论血清总胆汁酸测定在新生儿黄疸的诊断中具有重要临床意义,有利于新生儿黄疸的早期诊治及预后。
Objective To explore the clinical significance of serum total bile acid （TBA） determination in the diagnosis and treatment of full-term neonatal jaundice. Methods Eighty-two cases of neonatal jaundice with full clinical data were divided into severe jaun- dice group （ A group ）, mild jaundice group { B group ）, and physiological jaundice group （ C group ）. The levels of serum total bile acid （ TBA ） and other liver function indexes in each group were detected and compared. Results （1）The levels of TBA, TBTL （ total bilirubin ）, DBTL（ di- rect bilirubin ） and ALT{ alanine aminotransferase） in group A and group B were higher than those of group C,the difference was statistically significant （ P 〈 0. 05） ;There was no significant difference （P 〉 0. 05） between the B group and the C group of GGT（ gamma gamma Valley ammonia acyl transfer peptide ）. （2）A, B two groups of TBA levels and TBTL, DBTL, GGT, ALT of the liver function indicators had linear cor- relation. （3）The levels of TBTL and TBA in A and B group were significantly decreased compared with before treatment, the difference was sta- tistically significant （ P 〈 0.05 ） , but the regression time of TBA and TBIL in A group were longer than the B group, the difference was statisti- cally significant （ P 〈 0.05 ）. Conclusion The determination of serum total bile acid in the diagnosis of neonatal jaundice has important clini- cal significance, it is conducive to the early diagnosis and prognosis of neonatal jaundice.
出处
《潍坊医学院学报》
2017年第1期53-55,共3页
Acta Academiae Medicinae Weifang
关键词
总胆汁酸
新生儿黄疸
胆汁淤积
Total bile acid
Neonatal jaundice
Cholestasis
