摘要
补中益气汤由李东垣创制,具有补中益气、升阳举陷、甘温除热的功效,临床上常用于治疗与脾胃气虚及中气下陷等脾胃功能障碍有关的诸多病证。现代学者对补中益气汤的有效成分、药理作用、作用机制、质量标准和配伍理论等方面进行了广泛的研究。其中有关其配伍规律的研究的文献报道较多,但未见综述整理,该文旨在从该方药物配伍对其有效成分及药理作用的影响两方面入手,总结补中益气汤配伍规律的现代研究成果。研究表明,无论有效成分的研究还是药理作用的研究都证明了补中益气汤配伍的合理性,任何单味药物或药对的缺失,其药效均不如原方。在配伍对有效成分的影响方面,方中君臣药均可增加橙皮苷的含量,佐药可降低甘草酸的含量;在配伍对药理效应的影响方面,君药黄芪及益气健脾药味配伍在免疫调节方面起主导作用,而佐使药柴胡、升麻起关键性增效作用;同时益气升阳药味配伍对脾虚证模型动物的病理状态和代谢的调节有不可替代的作用。这些研究成果充分阐明了补中益气汤的方药配伍所涉及的中医基础理论和方剂学理论的科学性。经典方剂的配伍理论能充分体现中医基础理论及方剂学理论,而对经典方剂配伍规律的研究有利于更好地诠释中医基础理论,同时更好地指导临床应用及科学研究。
Buzhong Yiqitang, which was created by LI Dong-yuan, has functions of tonifying middle- energizer and Qi, ascending up spleen-Qi and Yang, removing heat with sweet-warm herbs. In clinic, the decoction was used to treat spleen stomach Qi deficiency, middle-energizer sinking and other diseases related to spleen-stomach dysfunction. Modern researchers have expounded its chemical composition, pharmacological actions, mechanisms of action, quality standards and compatibility. There are a large number of papers on the compatibility discipline, but without any review summarization. This review aimed to summarize modern researches of compatibility discipline of Buzhong Yiqitang in the aspects of compatibility principle and chemical composition. The results showed the rational composition of Buzhong Yiqitang. That is to say, the lack of any single herb or herbal pair could impact the efficacy of the original prescription. In terms of the impact on chemical composition, both of the sovereign medicine and the minister medicine played a dominant role in increasing the content of hesperidin and the assistant medicine reduced the content of glycyrrhizic acid; with respect to the impact of pharmacological effectiveness, the sovereign medicine and the drug combination with tonifying Qi played the role in modulating immune, while the assistant medicines Cimicifugae Rhizoma and Buplenri Radix played a synergistic effect. Meanwhile, the drug combination with medicines for tonifying Qi and raising Yang played an irreplaceable role in modulating pathological state and metabolism of animals with insufficiency of the spleen. These results fully prove the basic theory of TCM and the theory of dosimetry. The study for compatibility principles of classical prescriptions is conducive to better interpreting the theory of the TCM and guiding clinical application and scientific researchers.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2017年第7期221-226,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
山西省重点研发计划重点项目(201603D3114005)
关键词
补中益气汤
配伍规律
有效成分
药理作用
Buzhong Yiqitang
compatibility discipline
chemical composition
pharmacological action
