摘要
目的分析脉冲冲洗术对急性骨与软组织感染患者炎性介质因子表达的影响及临床意义。方法选取2011年5月-2016年5月218例骨与软组织感染患者为研究对象,按照清除创面感染方式的不同,分为传统组107例,以凡士林纱布覆盖的方式进行抗感染处理;研究组111例,以脉冲冲洗术进行清创处理,比较两组患者炎性应激因子超敏C-反应蛋白(hs-CRP)、肿瘤细胞因子-α(TNF-α)、干扰素-γ(IFN-γ)、血沉(ESR)与其他炎性因子白介素-1β(IL-1β)、白介素-6(IL-6)、白介素-8(IL-8)、白介素-10(IL-10)表达的变化及创面正常愈合效果的比较。结果研究组炎性应激指标hs-CRP(2.31±0.56)pg/ml、IFN-γ(22.57±3.76)pg/ml、ESR(13.67±3.82)mm/h表达比传统组下降明显,差异有统计学意义(P<0.05),TNF-α(38.57±2.76)pg/ml表达比传统组显著上升,差异有统计学意义(P<0.05);研究组其他炎性因子IL-1β(3.21±0.83)pg/ml、IL-6(78.82±12.84)pg/ml、IL-8(81.46±13.76)pg/ml、IL-10(4.67±2.92)pg/ml表达均较传统组显著下降,差异有统计学意义(P<0.05)。结论脉冲冲洗术在急性骨与软组织感染中具有良好的抗菌消炎作用,可明显改善患者炎性应激因子与其他炎性因子的表达水平,是一种操作性较高的、对治疗感染有积极意义的临床术式。
OBJECTIVE To investigate the effects and clinical significance of pulse washing on the expression of inflammatory mediators in patients with acute bone and soft tissue infections.METHODS A total of 218 patients with bone and soft tissue infection from May 2011 to May 2016 were retrospectively selected and divided into two groups according to the different infections wounds methods.The traditional group of 107 patients was treated with Vaseline gauze for anti-infection treatment,and the study group of 111 cases was taken with pulse processing for debridement treatment.The changes of the expression levels of inflammatory stress factors of hypersensitive C-reactive protein,tumor cytokine-alpha,interferon-gamma,and erythrocyte sedimentation rate（hs-CRP,TNF-α,IFN-γ,ESR）and other inflammatory factors of interleukin-1β,interleukin-6,interleukin-8,and interleukin-10（IL-1β,IL-6,IL-8and IL-10）and wound normal healing effect were compared.RESULTS The expression of inflammatory stress factors（hs-CRP[（2.31 ± 0.56）pg/ ml],IFN-γ [（22.57 ± 3.76）pg/ ml]and ESR[（13.67±3.82）mm/h]of study group were significantly decreased compared with those of traditional group（P〈0.05）.The expression of TNF-α（（38.57 ± 2.76）pg/ml）of study group was significantly higher than that of traditional group（P〈0.05）.The other inflammatory cytokines of IL-1β[（3.21±0.83）pg/ml],IL-6[（78.82±12.84）pg/ml],IL-8[（81.46±13.76）pg/ml],and IL-10[（4.67±2.92）pg/ml]of study group were significantly decreased than those of control group（P〈0.05）.CONCLUSIONPulse washing has a good anti-bacterial and anti-inflammatory effect in acute bone and soft tissue infection.It can significantly improve the expression of inflammatory stress factors and other inflammatory factors,and promote the wound healing.It is of high operability and positive clinical significance in the treatment.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第6期1345-1348,共4页
Chinese Journal of Nosocomiology
关键词
脉冲冲洗术
急性骨与软组织感染
炎性介质因子
Pulse washing
Acute bone and soft tissue infections
Inflammatory mediators
