摘要
目的分析浙江省中年居民体质指数(BMI)、腰围身高比(WHtR)及膳食脂肪摄入情况与血清瘦素水平的相关性。方法采用分层随机抽样法,于2014年12月从浙江省抽取4个区县513名30~65岁调查对象,采用3天24小时膳食回顾法进行膳食调查,同时测量其身高、体重、腰围及血清瘦素浓度,分析体格指标及膳食脂肪与瘦素的关系。结果女性血清瘦素水平高于男性(P<0.001)。BMI、WHtR与瘦素水平均呈正相关,相关系数男性和女性分别为0.488、0.576和0.453、0.333(P<0.0001)。调整WHtR后女性BMI与瘦素水平仍有相关性(r=0.321,P<0.0001),调整BMI后男性WHtR与瘦素水平仍有相关性(r=0.354,P<0.0001),其余指标相关性消失。偏最小二乘回归结果显示男性WHtR(β=0.27)标准化偏回归系数高于BMI(β=0.21),而女性则为BMI(β=0.26)高于WHtR(β=0.20)。男性总能量、总脂肪、单不饱和脂肪酸(MUFA)与瘦素水平呈负相关(P<0.05),而女性多不饱和脂肪酸(PUFA)供能比及(PUFA+MUFA):SFA与瘦素水平呈正相关(P<0.05)。对男性调整WHtR、对女性调整BMI,可见男性总脂肪、MUFA仍与瘦素呈负相关(P<0.05);女性PUFA供能比与瘦素呈正相关(P<0.05),其余指标相关性消失。结论肥胖程度与瘦素水平呈正相关关系,在评价肥胖与瘦素水平关系时,男性WHtR与瘦素水平相关性更强,女性BMI与瘦素水平相关性更强;男性总脂肪摄入量、MUFA与瘦素水平呈负相关,女性PUFA供能比与瘦素水平呈正相关。
Objective To investigate the association between body mass index（BMI）,waist-to-height ratio（WHtR） and dietary fat with serum leptin concentration.Methods A three-day 24-h dietary recall method was conducted on 513 participants aged30-65 years who were randomly selected from Zhejiang Province in 2014 to investigate usual fat intake. In addition,parameters including height,weight,waist and serum leptinconcentration of participants were measured and determined by physical examination and laboratory detection. Results Concentration of serum leptin in women was significantly higher than that in men（ P 0.001）. Both BMI and WHtR were positively correlated with serum leptin level（ men： r=0.488 and 0.576,women： r =0.453 and 0.333,P〈0.0001）,but only correlation of WHtR that men（r=0.354,P〈0.0001） and BMI in women（r=0. 321, P 0.0001） remained when BMI and WHtR were controlled respectively. Standardized partial regression coefficient of WHtR（β =0.27） was higher than that of BMI（β=0.21） in men while in women the coefficient of BMI（β=0.26）was higher than that of WHtR（β = 0.20）. Serum leptin level was negatively correlated with total energy,total fat and MUFA in men（P〈0.05）,but the correlation between total energy and leptin was disappeared when WHtR was controlled for. Serum leptin level was positively correlated with the proportion of PUFA from total energy and（PUFA ＋MUFA） ∶ SFA in women（P〈0.05）,while only the correlation between the proportion of PUFA from total energy and leptin remained when BMI was controlled for. Conclusion Obesity degree was gender-specifically positively correlated with serum leptin level,which indicated different obesity indicators should be used for men and women when analyzing serum leptin. Serum leptin was negatively correlated with total fat and MUFA in men,while positively correlated with the proportion of PUFA from total energy in women.
出处
《卫生研究》
CAS
CSCD
北大核心
2017年第2期173-178,共6页
Journal of Hygiene Research
基金
国家自然科学基金(No.81372992)
关键词
体质指数
腰围身高比
膳食脂肪
瘦素
body mass index（BMI）
waist-to-height ratio（WHtR）
dietary fat
leptin
