摘要
目的探讨降钙素原(PCT)在慢性阻塞性肺疾病急性加重期(AECOPD)患者抗感染治疗中的应用价值。方法回顾性分析自2015年9月至2016年9月解放军210医院收治的78例AECOPD患者的临床资料。将78例患者随机分为常规治疗组(n=39)和PCT指导治疗组(n=39)。常规治疗组根据临床症状、相关指南以及医师经验使用抗菌药物;PCT指导治疗组根据患者的血清PCT值指导临床抗菌药物的应用。观察两组患者的临床指标、有效率、住院时间、抗菌疗程、住院费用、抗菌药物使用率、病情加重率、病死率、二重感染率等。结果治疗后两组患者的临床指标、有效率、病死率、病情加重率等比较,差异均无统计学意义(P>0.05);PCT指导治疗组的抗菌药物使用率、住院天数、住院费用、抗菌药物使用时间、二重感染率均较常规治疗组偏低,差异有统计学意义(P<0.05)。结论 PCT检测对AECOPD患者的抗感染治疗具有指导作用,能缩短抗菌药物使用以及住院时间,有效避免抗菌药物的滥用,减少二重感染的发生。
Objective To investigate the value of the procalcitonin（PCT） inspection result,which conducted anti-infection therapy in patients with the acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods A retrospective study was performed on 78 AECOPD patients received in No. 210 Hospital of PLA from September 2015 to September 2016. Patients were randomly divided into the conventional group（ n = 39） and the PCT guided group（ n = 39）. The therapeutic schedule of antibacterial agents in the conventional group was according to clinical feature,clinical guidance and clinician experience; in the PCT guided group,the serum PCT index was used as a guideline of antibacterial agents. The clinical indicators,effective rate,length of hospital stay,antibiotic treatment,hospitalization costs,antibacterial agents utilization rate,rate of disease progression and mortality,and co-infection rate between the two groups were observed. Results After the treatment,there was no statistical significance in the clinical indicators,effective rate,rate of disease progression and mortality between the two groups（ P〉0. 05）. The antibacterial agents utilization rate,length of hospital stay,hospitalization costs,course of treatment and co-infection rate in the PCT guided group were significantly lower than those in the conventional group（ P〈0. 05）. Conclusion The PCT inspection result has a guiding function towards the antibiotic treatment of AECOPD patients,it can shorten antibacterial drug use and the hospitalization time,effectively avoid the abuse of antibiotics and reduce co-infection.
出处
《临床军医杂志》
CAS
2017年第2期165-168,共4页
Clinical Journal of Medical Officers
关键词
降钙素原
慢性阻塞性肺疾病
急性加重期
Procalcitonin
Chronic obstructive pulmonary disease
Acute exacerbation
