摘要
目的探讨联合应用白三烯受体拮抗剂治疗小儿中、重度变应性鼻炎(allergic rhinitis,AR)的临床疗效。方法随机将62例中、重度AR患儿分为常规治疗组和联合治疗组,每组患者各31例,常规治疗组用第二代抗组胺药口服、鼻用糖皮质激素喷鼻治疗;联合治疗组在常规治疗组的基础上加用孟鲁司特钠咀嚼片口服,两组患者疗程均为4周。对两组患儿在治疗前、治疗4周结束时及治疗结束后3个月鼻部症状视觉模拟量表(VAS)评分及总有效率进行比较。结果 1鼻部症状VAS评分每组患者治疗前与治疗4周结束时、治疗结束后3个月分别比较差异均具有统计学意义(P均<0.05);治疗4周结束时、治疗结束后3个月,联合治疗组和常规治疗组分别比较,差异均有统计学意义(P均<0.05);2总有效率:治疗4周结束时、治疗结束后3个月,联合治疗组(总有效率为96.67%、90.00%)和常规治疗组(总有效率83.33%、73.33%)分别比较,差异均有统计学意义(P均<0.05);常规治疗组治疗4周结束时和治疗结束后3个月总有效率比较,差异具有统计学意义(P<0.05),而联合治疗组差异则无统计学意义(P>0.05)。结论白三烯受体拮抗剂联合鼻用糖皮质激素和第二代抗组胺药治疗小儿中、重度AR可以增强和巩固疗效。
Objective To investigate the clinical effect of combined use of leukotriene receptor antagonist in children with moderate to severe allergic rhinitis （AR）. Methods 62 patients with moderate to severe AR were randomly divided into conventional treatment group and combined treatment group （31 cases in each group）. The patients in the routine treatment group received oral administration of second-generation antihistamines and eorticosteroid nasal spray, while those in the combined treatment group were given, on the basis of the routine treatment, Montelukast sodium chewable tablets. The treatment courses of both groups were 4 weeks. Visual analogue scale （VAS） scores and total effective rates were compared between the two groups at the time-points before treatment, at the end of treatment and at 3 months after treatment. Results ①Compared with VAS scores before treatment, the scores at the end of treatment and 3 months after treatment were significantly reduced in both groups （ all P 〈 0.05 ）. The differences of scores between the combined treatment group and routine treatment group at the end of treatment and 3 months after treatment were statistically significant respectively （ both P 〈 0.05 ）. ②The differences of total effective rates between the combined treatment group and routine treatment group at the end of treatment and 3 months after treatment were statistically significant respectively （ both P 〈 0.05 ）. In addition, the difference between the total effective rate at the end of treatment and 3 months after treatment in the conventional treatment group was statistically significant （P 〈 0.05 ）, while this in the combined treatment group was insignificant （ P 〉 0.05 ）. Conclusion Leukotriene receptor antagonists combined with nasal corticosteroids and second-generation antihistamines can enhance and consolidate the therapeutic effect in the treatment of moderate to severe AR in children.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
2017年第1期71-74,共4页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
关键词
鼻炎
变应性
白三烯受体拮抗剂
抗组胺药
治疗结果
Rhinitis, allergic
Leukotriene receptor antagonist
Antihistamine
Treatment outcome
