期刊文献+

一种改进的蛋白质相互作用网络全局比对算法 被引量:1

Improved Algorithm for Global Alignment of Protein Interaction Networks
下载PDF
导出
摘要 改进更新匹配节点对的邻居节点得分之后的节点相似性得分计算方法,对匹配节点对的邻居节点相似性得分进行更新,综合使用节点间生物相似性得分、网络拓扑结构相似性得分和相互作用相似性得分对蛋白质相互作用网络进行匹配比对和迭代调整最佳匹配,以使得匹配结果更加贴近生物真实性.实验结果表明,给出的蛋白质相互作用网络全局比对算法整体上获得了更高的比对总分和检测到较多拥有共同基因本体的蛋白质对数. The computational method of similarity score between nodes is improved when the scores of neighbors of matched node pairs have been updated, and the similarity scores of neighbors of matched node pairs are updated depending on the improved computa- tional method. By combining biological similarity score with network topology similarity score and interaction similarity score between nodes, the two protein interaction networks are aligned and the optimal matches are adjusted iteratively in order to obtain the matched results that are more close to the biological authenticity. Experimental results show that compared with existing algorithms, on the whole, the presented algorithm for global alignment of protein interaction networks obtains higher alignment scores and detects more protein pairs that have common gene ontology.
作者 周钰乔 钟诚
出处 《小型微型计算机系统》 CSCD 北大核心 2017年第4期808-812,共5页 Journal of Chinese Computer Systems
基金 国家自然科学基金项目(61462005)资助 广西自然科学基金项目(2014GXNSFAA118396)资助
关键词 蛋白质相互作用网络 全局比对 边正确率 比对总分 基因本体 protein-protein interaction networks global alignment edge correctness sum score of alignment gene ontology
  • 相关文献

参考文献2

二级参考文献29

  • 1CHINDELEVITCH L, LIAO C-S, BERGER B. Local optimization for global alignment of protein interaction networks[C] / / Proceed?ings of Pacific Symposium on Biocomputing 2010. Singapore: World Scientific Publishing, 2010: 123 - 132.
  • 2KEELEY B P, YUAN B, LEWITTER F, et at. PathBLAST: a tool for alignment of protein interaction networks[J]. Nucleic Acids Re?search, 2004, 32( Web-Server-Issue): 83 - 88.
  • 3LI Z P, ZHANG S H, WANG Y, et at. Alignment of molecular net?works by integer quadratic programming[J]. Bioinformatics, 2007, 23( 13): 1631 -1639.
  • 4SINGH R, XUJ B, BERGER B. Pairwise global alignment of pro?tein interaction networks by matching neighborhood topology[C I / / RECOMB'07: Proceedings of the 11th Annual International Confer?ence on Research in Computational Molecular Biology, LNCS 4453. Berlin: Springer-Verlag, 2007: 16 - 31.
  • 5LIAO C-S, LU K H, BAYM M, et at. IsoRankN: spectral methods for global alignment of multiple protein networks[J]. Biocomputing, 2009, 25( 12): 253 -258.
  • 6KUCHAIEV 0, PRZUU N. Integrative network alignment reveals large regions of global network similarity in yeast and human[J] . Bioinformatics, 2011, 27( 10): 1390 -1396.
  • 7ATlAS N, SHARAN R. Comparative analysis of protein networks: hard problems, practical solutions[J]. Communications of the ACM, 2012, 55(5): 88-97.
  • 8谭军.蛋白质相互作用网络比对的自适应混合并行算法研究[D].上海:上海大学,2013.
  • 9KUHN H W. The Hungarian method for the assignment problem[M] / / 50 Years of Integer Programming 1958-2008. Berlin: Springer-Verlag, 2010: 29 -47.
  • 10KUHN H W. A tale of three eras: the discovery and rediscovery of the hungarian method[J]. EuropeanJournal of Operational Re?search, 2012, 219(3): 641 -651.

共引文献4

同被引文献2

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部