摘要
目的:研究浆细胞性乳腺炎(PCM)组织中白细胞介素-1β(IL-1β)及肿瘤坏死因子-α(TNF-α)的表达及其临床意义。方法:选择2013年11月到2016年4月在内蒙古自治区人民医院就诊的PCM患者50例作为观察组,选择上述观察组患者中距炎性肿物边缘>3cm且镜检为正常乳腺组织23例作为对照组,比较两组组织中IL-1β及TNF-α的表达,分析不同临床分期和分型者IL-1β及TNF-α的表达及相关性。结果:观察组组织中的IL-1β及TNF-α的表达水平均分别明显高于对照组差异有统计学意义(P<0.05);观察组急性期及亚急性期的患者IL-1β及TNF-α水平分别明显高于慢性期,且急性期明显高于亚急性期,差异均有统计学意义(P<0.05);不同临床分型者的IL-1β及TNF-α水平相比差异均无统计学意义(P>0.05),依照PEARSON法分析相关性发现,观察组不同临床分期患者的IL-1β及TNF-α呈正相关(r=0.860,P=0.000)。结论:PCM组织中的IL-1β及TNF-α高表达,且两者对PCM的发展发挥了协同作用。
Objective：To study the expression of IL-1β and TNF-α in tissues of plasma cell mastitis（PCM） and its clinical significance.Methods：50 cases of patients with PCM who were treated in the Inner Mongolia Autonomous Region People’s Hospital from November 2013 to April 2016 were selected as observation group,and selected 23 cases of normal breast tissues those〉3 cm from the edge of the inflammatory mass and checked by microscopic examination of the patients as control group.The expression of IL-1 and TNF-in two groups were compared,and the expression and correlation of IL-1 and TNF-in different clinical stages and types were analyzed.Results：Expression levels of IL-1β and TNF-α in tissues in observation group were significantly higher than those in the control group,the difference was statistically significant（P〈0.05）.The levels of IL-1β and TNF-α in patients with acute and subacute stage were significantly higher than those in chronic phase,and the acute phase was significantly higher than that of subacute stage,the difference was statistically significant（P〈0.05）.The difference of expressions levels of IL-1β and TNF-α in different clinical classification was not statistically significant in observation group（P〉0.05）.According to the PEARSON analysis,the the expression of IL-1 B and TNF-αwas positively correlated in patients with different clinical stages in observation group（r=0.860,P=0.000）.Conclusion：The expressions of IL-1 B and TNF-α in PCM tissue is high,and they play a synergistic role on the development of PCM.
作者
王小龙
刘兴
苏依图
张文谦
周敏
曹中伟
WANG Xiao-long LIU Xing SU Yi-tu ZHANG Wen-qian ZHOU Min CAO Zhong-wei(Bao Ton Medical College, Baotou, Inner Mongolia, 014040, China Department of Auxiliary, Huanghua People＇s Hospital, Huanghua, Hebei, 061100, China Department of Pathology, Inner Mongolia Autonomous Region People＇s Hospital, Hohhot, Inner Mongolia, 010010, China Department of Thyroid and Breast Surgery, Inner Mongolia A utonomons Region People＇s Hospital, Hohhot, Inner Mongolia, 010010, China)
出处
《现代生物医学进展》
CAS
2017年第6期1110-1112,共3页
Progress in Modern Biomedicine
关键词
浆细胞性乳腺炎
组织
炎性因子
表达
相关性
Plasma cell mastitis
Tissue
Inflammatory factor
Expression
Correlation
