摘要
内体分拣转运复合体(endosomal sorting complex required for transport,ESCRT)是一种能够识别并分拣泛素化蛋白质货物的蛋白复合体,由四个亚复合体(ESCRT-0、ESCRT-Ⅰ、ESCRT-Ⅱ、ESCRT-Ⅲ)和一些辅助成分构成。研究表明,ESCRT途径能参与病毒的出芽过程、调控细胞自噬,并且与包括肿瘤和神经退行性疾病在内的重要疾病有关。因此,ESCRT复合体结构与功能研究对未来新型治疗药物的开发具有重要意义。该文综述了ESCRT的结构、各成员在多种生命活动中的功能、组装因子之间的互作关系以及ESCRT复合体的功能,旨在为日后深入研究ESCRT的作用机制开辟更科学的研究方向。
Endosomal sorting complex required for transport is a kind of protein complex which can identify and sort the ubiquitinated proteins.It consists of four sub complexes which include ESCRT-0,ESCRT-I,ESCRT-Ⅱ,ESCRT-Ⅲ,and some auxiliary complex.Some studies show that ESCRT pathway is involved in virus budding process,the regulation of autophagy,and it is related to several important diseases including human cancer,neurodegenerative diseases and so on.Therefore,the studies on the structures and functions of the ESCRT complex are of great significance for the development of new therapeutic drugs in the future.This article summarizes the components of ESCRT,the functions of each member in a variety of life activities,the interaction between assemble factors and the function of the ESCRT complex,aiming to develop a more scientific research direction for the intensive study of mechanism of ESCRT.
出处
《中国细胞生物学学报》
CAS
CSCD
2017年第2期215-222,共8页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:31370171,31371890)资助的课题~~
