摘要
目的分析血塞通序贯疗法治疗急性脑梗死的临床疗效及疾病成本负担。方法选取2014年6月—2016年3月鄂东医疗集团黄石市中心医院神经内科收治的急性脑梗死患者90例,采用随机数字表法分为对照组与试验组,每组45例。在常规治疗基础上,对照组患者给予注射用血塞通(冻干)治疗,试验组患者给予注射用血塞通(冻干)治疗7 d后改用血塞通分散片治疗;两组患者均连续治疗14 d。比较两组患者临床疗效,治疗前后欧洲卒中量表(ESS)评分和日常生活能力量表(ADL)评分、血液流变学指标(全血黏度、血浆黏度、血细胞比容及D-二聚体)、凝血功能指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)及纤维蛋白原(FIB)],并记录两组患者治疗总费用和药品费用及治疗期间不良反应发生情况。结果两组患者临床疗效及治疗前后ESS、ADL评分、全血黏度、血浆黏度、血细胞比容、D-二聚体、PT、APTT、TT、FIB比较,差异均无统计学意义(P>0.05);两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。试验组患者总费用和药品费用少于对照组(P<0.05)。结论血塞通序贯疗法与血塞通静脉滴注治疗急性脑梗死的临床疗效相当,均能有效减轻患者神经功能缺损程度并改善患者日常生活活动能力、血液流变学及凝血功能,且安全性均较高,但血塞通序贯疗法较血塞通静脉滴注的治疗总费用及药品费用更低,成本-效益更优。
Objective TO analyze the clinical effect and cost of disease burden of xuesaitong sequential therapy on acute cerebral infarction. Methods From June 2014 to March 2016, a total of 90 patients with acute cerebral infarction were selected in the Department of Neurology, Huangshi Central Hospital of Edong Medical Group, and they were divided into control group and test group according to random number table, each of 45 eases. Based on conventional treatment, patients of control . group received xuesaitong injection （freeze - drying） for 14 days, while patients of test group received xuesaitong injection （freeze - drying） for 7 days and xuesaitong dispersible tablets for the following 7 days. Clinical effect, ESS score and ADL score, index of hemorheology （ including whole blood viscosity, plasma viscosity, hematocrit and D-dimer） and blood coagulation （ including PT, APTT, TT and FIB ） before and after treatment were compared between the two groups, total treatment cost, drug cost and incidence of adverse reactions during the treatment were recorded. Results No statistically significant differences of clinical effect, ESS score, ADL score, whole blood viscosity, plasma viscosity, hematocrit, D-dimer, PT, APTT, TT or FIB was found between the two groups before or after treatment （ P 〉 0.05 ） , nor was incidence of adverse reactions between the two groups during the treatment （ P 〉 0. 05 ）. Total treatment cost and drug cost of test group were statistically significantly less than those of control group （ P 〈 0. 05 ）. Conclusion Xuesaitong sequential therapy has similar clinical effect with intravenous drip of xuesaitong injection in treating acute cerebral infarction, both of them can effectively reduce the degree of neurological deficit, improve the activities of daily living, hemorheology and blood coagulation, with relatively high safety, but xuesaitong sequential therapy can more effectively reduce the total treatment cost and drug cost than intravenous drip of xuesailong injection has better cost - effectiveness.
出处
《实用心脑肺血管病杂志》
2017年第2期79-82,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
脑梗死
序贯疗法
药物毒性
治疗结果
Brain infarction
Sequential therapy
Drug toxicity
Treatment outcome
