摘要
目的比较PCOS合并T2DM、PCOS合并AGT、PCOS IR、PCOS Non-IR之间的临床生化差异,分析PCOS合并T2DM患者的临床特征。方法选择2013年6月~2016年1月就诊于黑龙江中医药大学附属第一医院妇科门诊、资料完整的PCOS患者217例,分为4组:PCOS+T2DM组(30例)、PCOS+AGT组(69例)、PCOS+IR组(糖耐量正常,87例)、PCOS+NonIR组(糖耐量正常,31例)。结果前3组患者的腰臀比显著高于第4组(P<0.05);PCOS+T2DM组患者的收缩压、病程显著高于PCOS+IR组和PCOS+Non-IR组(P<0.05)。前3组SHBG均显著低于PCOS+Non-IR组(P<0.05)。PCOS+T2DM组患者FPG、2h血糖、HOMA-IR及LDL显著高于后3组(P<0.05);PCOS+T2DM组患者LN(HOMA-β)显著低于PCOS AGT和IR患者,2h胰岛素显著低于PCOS+AGT组(P<0.05);PCOS+AGT组患者FPG、2h血糖、2h胰岛素显著高于后两组(P<0.05);PCOS+T2DM组和PCOS+AGT组患者TG、TC/HDL、TG/HDL、LDL/HDL、APOB/APOA均显著高于PCOS+IR组、PCOS+Non-IR组(P<0.05);PCOS+IR组TG/HDL、LDL/HDL、APOB/APOA显著高于PCOS+Non-IR组(P<0.05)。结论 PCOS合并T2DM患者病程较长,β细胞敏感度降低,较AGT和糖耐量正常的患者具有较高的血脂水平。
Objective To provide an evidence to type 2 diabetes with PCOS patients, the study compared the clinical features between T2DM,AGT, 1R and Non -IR patients. Methods A analysis on 30 T2DM ,69 impaired glucose tolerance,87 IR and 31 Non -IR patients of PCOS was performed. Results WHR of the former three groups was significantly higher than the non - IR group（P 〈 0. 05）. The systolic pressure and progress of T2 DM patients were significantly higher than IR and Non - IR groups （ P 〈 0. 05 ）. In T2 DM, AGT and IR groups, SHBG level was significantly lower than Non -IR group. In PCOS ＋ T2DM group, FPG,2h blood glucose, HOMA -IR and LDL were significantly higher than the three latter groups（ P 〈 0.05 ）. In PCOS ＋ T2DM group, LN （HOMA - 15） was significantly lower than AGT and IR groups,2h blood insulin was significantly lower than AGT group （P 〈 0.05）. PCOS AGT group, FPG,2h blood glucose,2h blood insulin were significantly higher than IR and non -IR. In PCOS ＋ T2DM and AGT groups,TG,TC/HDL,TG/HDL, LDL/HDL, APOB/APOA was significantly higher than IR group and non- IR group （P 〈 0.05）,whlile TG/HDL, LDL/HDL,APOB/APOA of IR group was significantly higher than non - IR group（P 〈 0.05）. Conclusion T2DM patients with PCOS have long progress, with β - cell sensitivity decreased and had higher lipid level than AGT,IR patients.
出处
《医学研究杂志》
2017年第3期48-51,共4页
Journal of Medical Research
基金
国家重大科技专项基金资助项目(201207001)
国家中医药管理局国家中医临床研究基地业务建设科研专项基金资助项目(JDZX2012039)
国家中医药管理局全国名老中医药专家传承工作室建设项目(2014-09)
关键词
多囊卵巢综合征
糖尿病
血脂
病程
Polyeystic ovary syndrome
Type 2 diabetes mellitus
Lipid
Progress
