摘要
目的分析抗甲状腺药物(ATDs)导致的粒细胞缺乏症的临床特征。方法对北京协和医院14年间36例患者的临床资料进行回顾性分析和总结。结果发生粒细胞缺乏患者的年龄16~62岁。88.9%的粒细胞缺乏发生在大剂量ATD治疗时。91.7%是在治疗3个月内出现。最长1例患者为持续治疗8个月时发生粒细胞缺乏。99.4%的患者继发感染。结论ATDs诱导的粒细胞缺乏症,与年龄、性别无关。与药物种类无关,但存在剂量依赖性。
Objective In this article, we report and discuss the clinical presentation of antithyroid drug（ATD） -induced agranulocytosis. Methods We retrospectively studied 36 cases of ATD - induced agranulocytosis over the past 14 years in PUMC hospital. Results ATD - induced agranulocytosis patient＇s age ranged of 16 - 62 years old. 88.9% of ATD - induced agranulocytosis occured with a large ATD treatment. 91.7% patients occured in the first three month of drug therapy. A case occured agranulocytosis when 8 months duration. 94.4% patients occurs secondary infections. Conclusion This study showed that ATD - induced agranulocytosis considered to be dose dependent, not irrelevant to sex, age and the drug.
出处
《医学研究杂志》
2017年第3期87-90,共4页
Journal of Medical Research
