摘要
[目的]通过分析三种常见脑小血管病（CSVD）MRI标记患者的临床特征，探讨CSVD的危险因素，并推测其发病机制以及预测其发展和演变。[方法]选择在MRI上拥有白质高信号（white matter hyper-tensity，WMH）、腔隙、血管周围间隙（perivascular space，PVS）这三种常见CSVD的MRI标记的患者作为研究对象，收集其一般资料，测定分析其空腹血同型半胱氨酸（Hcy）、血尿酸（UA）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平。[结果]CSVD组中：年龄、吸烟史、Hcy为其危险因素；WMH组中：性别（男）、年龄、糖尿病史、Hcy为其危险因素，HDL-C为其保护因素；腔隙组中：年龄、吸烟、LDL-C为其危险因素，HDL-C为保护因素；PVS组中：年龄、吸烟、Hcy、TG为其危险因素。[结论]高龄、男性、吸烟史、Hcy、糖尿病史、高LDL-C、高TG是CSVD的危险因素，吸烟史作为CSVD的危险因素风险强度较高，而HDL-C为CSVD的保护因素。
[Objective]To explore the risk factors of CSVD through the analysis of clinical characteristics of MRI markers of three common cerebral small vessel disease （CSVD） in patients, and speculate the mecha- nism and prediction of its development and evolution.[Methods]Patients of the three common CSVD MRI markers on the MRI with white WMH （white matter hypertensity）, lacunar, perivascular spaces （perivascular space, PVS） were selected as the subjects; their general information was collected , and the fasting blood ho- moeysteine （Hcy）, serum uric acid （UA）, three acyl glycerol （TG）, total cholesterol （TC）, high density lip- oprotein cholesterol （HDL-C） and low density lipoprotein cholesterol （LDLC） levels were analyzed. [Results] In the CSVD group： age, smoking history, Hcy were the risk factors; in the WMH group： gender （male）, age, history of diabetes, Hcy were the risk factors, HDL-C was the protective factor; in rhe lacunar group： age, smoking, LDL-C were the risk factors, and HDL-C was the protective factor. In the PVS group： age, smoking, Hcy, TG were the risk factors.[Conclusion]Advanced age, male, smoking history, Hcy, history of diabetes, high LDL C, high TG are risk factors for CSVD. Smoking history is a high risk factor for CSVD, while HDL-C is a protective factor for CSVD.
出处
《医学临床研究》
CAS
2017年第3期435-438,共4页
Journal of Clinical Research
