摘要
目的:研究门冬氨酸鸟氨酸注射液联合乳果糖治疗肝性脑病(HE)的临床效果。方法:将笔者所在医院收治的46例HE患者随机分为观察组和对照组,各23例,对照组患者在常规治疗的基础上给予乳果糖溶液口服或灌肠治疗,观察组患者在对照组基础上加用门冬氨酸鸟氨酸静脉滴注治疗,两组患者均治疗14 d。记录两组患者治疗前后血氨水平、肝功能指标变化及HE分期改变,比较两组患者治疗总有效率及不良反应发生率。结果:两组患者治疗后血氨水平及肝功能指标均较治疗前显著改善,差异有统计学意义(P<0.01),且观察组患者治疗后血氨水平及肝功能指标显著优于对照组,差异有统计学意义(P<0.01);两组患者治疗前HE分期比较,差异无统计学意义(P>0.05),治疗后观察组HE分期改善情况显著优于对照组,差异有统计学意义(P<0.05);观察组患者治疗总有效率91.3%,显著高于对照组的65.2%(P<0.05);两组患者治疗期间不良反应发生率比较差异无统计学意义(P>0.05)。结论:门冬氨酸鸟氨酸注射液和乳果糖联合治疗肝性脑病效果显著,安全性好,值得推广应用。
Objective： To study the clinical effect of L-ornithine-L-aspartate injection combined with Lactulose in the treatment of hepatic encephalopathy（HE）.Method： In our hospital, 46 cases of HE patients were randomly divided into observation group and control group with 23 cases in each group.The contral group were treated with Lactulose oral or enema treatment on the basis of conventional therapy, patients in the observation group used L-ornithine- L-aspartate intravenous infusion therapy based on the control group.The patients were treated for 14 d.Before and after treatment, the blood ammonia level, liver function index and HE stage were recorded and compared between the two groups.The total effective rate and adverse reaction rate were compared between the two groups.Result： Patients of the two groups after treatment, the level of blood ammonia and liver function indexes were significantly improved compared with before treatment（P〈0.01）, and the patients in the observation group after treatment, the level of blood ammonia and liver function index were significantly higher than those of the control group（P〈0.01）.HE stage of the two groups had no significant difference（P〉0.05）, after treatment, HE stage in the observation group improved significantly compared with control group（P〈0.05）, the total efficiency rate of the observation group（91.3%） was significantly higher than that of the control group of 65.2%（P〈0.05）, adverse reactions during treatment of the two groups had no significant difference（P〉0.05）.Conclusion： L-ornithine-L--aspartate injection combined with Lactulose has significant effect on hepatic encephalopathy, good safety, it is worthy of popularization and application.
出处
《中外医学研究》
2017年第9期3-5,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
肝性脑病
门冬氨酸鸟氨酸
乳果糖
Hepatic encephalopathy
L-ornithine-L-aspartate
Lactulose
