摘要
目的:本研究以淡渗利湿法立论,旨在初步评价其在治疗慢性肾炎蛋白尿以及预防肾脏纤维化的作用,为慢性肾炎蛋白尿的治疗提供有效方法。方法:选取济宁市中医院住院收治的慢性肾炎患者56例,随机分为观察组和对照组,每组28例;对照组采用氯沙坦钾治疗,观察组在对照组治疗的前提下,联合淡渗利湿中药方治疗6个月后,采用酶联免疫吸附法测定血清LN、CIV、TIMP-1指标的值,全自动生化仪测定24 h尿蛋白定量。比较2组治疗前、后以及2组间血清LN、CIV、TIMP-1指标以及24 h尿蛋白定量的变化。结果:2组治疗后的24 h尿蛋白定量均较治疗前明显减少,血清LN、CIV、TIMP-1水平较治疗前减少差异有统计学意义(P<0.05)。观察组治疗后LN、CIV、TIMP-1水平较对照组明显减少(P<0.05)。结论:淡渗利湿法联合氯沙坦钾治疗慢性肾炎合并蛋白尿患者,可以明显减少蛋白尿,对于预防肾间质纤维化具有一定的临床意义。
Objective：To evaluate the effect of inducing diuresis with bland drugs in treating chronic nephritis albuminuria and its function of preventing renal fibrosis .Methods：Fifty-six patients with chronic nephritis were randomly divided into Chinese medi-cine （ CM） group and western medicine （ WM） group with 28 cases in each group .WM group was treated with losartan potassium 100 mg/d, while CM group was treated with prescription with the function of inducing diuresis combined with losartan .After 6 months treatment , 24-hour urine protein , the value of serum laminin （ LN） , type IV collagen （ CIV） , and tissue inhibitor of ma-trix metallo proteinase-1 （TIMP-1） were compared between the two groups .Results：24-hour urine protein of the both groups de-creased obviously after treatment compared with that before the treatmrnt （P〈0.05）.The level of LN, CIV and TIMP-1 after the treatment decreased obviously compared with those before the treatmrnt （P〈0.05）.The level of LN, CIV and TIMP-1 of CM group decreased obviously compared with those of the WM group （ P〈0.05 ） .Conclusion： Treatment of inducing diuresis with bland drugs may reduce 24-hour urine protein effectively compared with western medicine and possibly prevent fibrosis of kidney interstitium.
出处
《世界中医药》
CAS
2016年第11期2314-2316,共3页
World Chinese Medicine
基金
济宁市中医药科技项目(编号:LC2012023)
关键词
淡渗利湿法
慢性肾炎
蛋白尿
纤维化
Weak permeability lishi method
Chronic nephritis
Proteinuria
Fibrosis
