摘要
目的:探讨补肾活血中药方二补助育汤对胚泡着床障碍小鼠子宫内膜容受性的影响。方法:制备小鼠胚泡着床障碍模型,研究其子宫内膜SCFmRNA、HOXA-10 mRNA、LIF、ER、PR、整合素(αvβ3)表达的改变。结果:GnRHa+HMG+HCG超促排方案能降低子宫内膜容受性,而二补助育汤能够调控小鼠子宫内膜调控链间的相关调控因子的表达,从而改善子宫内膜容受性。结论:二补助育汤改善子宫内膜容受性的作用是肯定的,并且其作用途径是多靶点、多环节的。
Objective：To investigate the effects of Erbuzhuyu Decoction on endometrium receptivity of rats model with embryo im -plantation dysfunction .Methods：Rats model with embryo implantation dysfunction was prepared for the study on expression chan -ges of endometrial SCFmRNA , HOXA-10 mRNA, LIF, ER, PR andανβ3.Results：GnRHa＋, HMG＋, HCG scheme may re-duce the endometrium receptivity , and Erbu Zhuyu Decoction may regulate regulate the expression of relevant regulating factors in networks of rat endometrial microenvironment to improve endometrium receptivity .Conclusion：Erbu Zhuyu Decoction is bound to have the effect on endometrium receptivity and its activity pathway is multi-targeted and multi-linked.
出处
《世界中医药》
CAS
2016年第11期2367-2369,2374,共4页
World Chinese Medicine
基金
2012国家自然科学基金项目(编号:81273789)--二补助育汤调节子宫内膜容受性的效应机制及其与SCFmRNA表达相关性研究
2014国家自然科学基金项目(编号:81473721)--基于NK/M-CSF/NO通路的二补助育汤调节子宫内膜容受性效应机制相关性研究
