摘要
目的:探讨依达拉奉、丙戊酸钠联合治疗对脑卒中后继发性癫痫(PSE)的疗效及血清神经元特异性烯醇化酶(NSE)的影响。方法:82例PSE患者随机分为观察组和对照组各41例,均给予口服丙戊酸钠缓释片,观察组还给予静脉滴注依达拉奉1周。比较2组治疗前后癫痫发作次数、发作持续时间、痫样放电、累及导联数及血清(NSE)水平,并记录2组不良反应情况。结果:对照组和观察组总有效率分别为80.5%、95.1%,观察组高于对照组(P<0.05)。治疗后2组癫痫发作次数、每次发作持续时间均显著减少,其中治疗后观察组癫痫发作次数、每次发作持续时间低于对照组(P<0.05)。与治疗前比较,2组治疗后痫样放电、累及导联数均呈下降趋势,其中观察组痫样放电、累及导联数下降更明显(P<0.05)。2组治疗后血清NSE均降低,观察组治疗1月血清NSE低于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论:依达拉奉联合丙戊酸钠能够有助于控制PSE癫痫症状,提高疗效,且安全性高。
Objective： To explore the effects of Edaravone combined with Sodium Valproate treatment on clinical outcome and serum neuron-specific enolase （NSE） level of post stroke epilepsy （PSE） patients. Methods： A total of 82 cases of PSE patients were divided into groups of control and observation with 41 in each. The both groups were given oral Sodium Valproate sustained-release tablets, and the observation group were given intravenous infusion of Edaravone for 1 week. The seizure frequency, duration of attacks, discharge of epileptic discharges, lead number and serum NSE levels were compared between the two groups before and after the treatment, and the adverse reactions were recorded. Results： The total effective rates of the control group and observation group were 80.5%, and 95.1% respecively with a significant difference （P〈0.05）. After the treatment, the frequency of seizures and duration of each attack were significantly reduced, espeially in the observation group （P〈0.05）. Afer the treatment, the numbers of the lead in the 2 groups were decreased and more significantly in the observation group （P〈0.05）, and so the the serum levels of NSE （P〈0.05）. No significant difference in adverse reactions rate was evident between the two groups （P〉0.05）. Conclusion： Edaravone combined with Sodium Valproate can be effective for controlling PES epilepsy symptoms with a high safety.
出处
《神经损伤与功能重建》
2017年第2期114-117,共4页
Neural Injury and Functional Reconstruction
