摘要
目的分析2型糖尿病合并非酒精性脂肪性肝病(NAFLD)患者血清分泌型卷曲相关蛋白5(SFRP5)水平与胰岛素抵抗(IR)的关系。方法选取2015年2月—2016年2月在新疆医科大学第五附属医院治疗的单纯2型糖尿病患者45例(DM组),单纯NAFLD患者41例(NAFLD组),2型糖尿病合并NAFLD患者36例(DM+NAFLD组),同期健康体检者50例作为对照组(NC组),均予常规体质监测,比较各组血清SFRP5、空腹血糖(FPG)、空腹胰岛素(FINS)等生化指标。采用Pearson及多元线性回归方法分析血清SFRP5水平与BMI、TC、TG等指标的相关性。结果各组受试者性别、年龄、收缩压和舒张压比较差异无统计学意义(F=1.406、1.204、2.044、1.946,P>0.05),NAFLD组和DM+NAFLD组BMI明显高于NC组和DM组(F=8.391,P=0.022);SFRP5水平:DM+NAFLD组<DM组<NAFLD组<NC组(F=11.283,P=0.000);胰岛素抵抗指数(HOMA-IR):NC组<NAFLD组<DM组<DM+NAFLD组(F-10.012,P=0.000);各组FPG、糖化血红蛋白(HbA_(1c))、FINS、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)比较差异均有统计学意义(F=10.391、9.213、10.832、8.743、9.111、8.948、9.472;P<0.05);血清SFRP5水平与BMI、FPG、HbA_(1c)、TC、TG、LDL-C和HOMA-IR呈负相关(r=-0.302、-0.401、-0.464、-0.221、-0.280、-0.321、-0.282,P均<0.05);多元线性逐步回归分析显示HOMA-IR是血清SFRP5的独立影响因素。结论 2型糖尿病合并NAFLD患者血清SFPR5水平明显降低,与患者胰岛素抵抗呈负相关,可能参与了疾病的发生发展。
Objective To investigate the relationship between serum tevels of secreted type 5 （ SFRP5 ） and insulin resistance （IR） in patients with type 2 diabetes mellitus complicated with nonalcoholic fatty liver disease （NAFLD）. Methods We selected 45 patients with type 2 diabetes from February 2015 to February 2016 in the Fifth Affiliated Hospital of Xin- jiang Medical University, they were included DM group, NAFLD group, DM ＋ NAFLD group, 50 healthy volunteer＇s were taken as control group （ NC group）. Physical fitness test, serum SFRPS, fasting blood glucose （ FPG ） , fasting insulin （FINS） and other biochemical indicators were tested. Pearson and multiple linear regression were used to analyze the correla- tion between serum SFRP5 level and BMI, TC, TG and other indicators. Results Each group of subjects＇ sex, age, systolic blood pressure and diastolic blood pressure had no significant difference （ F = 1. 406, F = 1. 204, F = 2. 044, F = 1. 946, P 〉 0. 05 ）, NAFLD group and DM ＋ NAFLD group＇ s BMI were significantly higher than that of NC group and DM group （F = 8.391,P =0.022）; SFRPS： DM＋NAFLDgroup 〈 DMgroup 〈 NAFLDgroup 〈 NCgroup （F =11.283,P = 0. 000） ; insulin resistance index （HOMA-IR） ： NC group 〈 NAFLD group 〈 DM group 〈 DM ＋ NAFLD group （ F = 10. 012, P = 0. 000 ） ; FPG, glycosylated hemoglobin （ HbA1c ）, FINS, total cholesterol （TC） , three glycerol （TG） , high density lipoprotein cholesterol （HDL-C） and low density lipoprotein cholesterol （LDL-C） showed no significant differences （F = 10.391,F =9.213, F =10.832, F =8.743, F =9.111,F =8.948, F =9.472;P 〈0.05）; the serum levels ofSFRP5 and BMI, FPG, HbA1c, TC, TG, LDL-C and HOMA-IR were negative related （r = -0. 302, r = -0.401, r = - 0. 464, r = - 0. 221, r = - 0. 280, r = -0. 321, r = - 0. 282, P 〈 0. 05 ） ; multiple linear stepwise regression analysis showed that HOMA-IR was an independent factor of serum SFRP5. Conclusion The level of serum SFPR5 in patients with type 2 diabetes mellitus combined with NAFLD was significantly decreased, which was negatively correlated with insulin resis- tance.
出处
《疑难病杂志》
CAS
2017年第4期360-363,共4页
Chinese Journal of Difficult and Complicated Cases
基金
新疆医科大学科研创新基金项目(XYDCX2015112)
新疆维吾尔自治区自然科学基金(2016D01C241)
关键词
糖尿病
2型
非酒精性脂肪性肝病
分泌型卷曲相关蛋白
胰岛素抵抗
Diabetes mellitus, type 2
Non alcoholic fatty liver disease
Secreted frizzled related protein 5
Insulinresistance
