摘要
主要以甘氨酸和4-二苯氨基苯甲醛为原料,通过还原氨化反应得到4-二苯胺-苯甲氨基乙酸,用叔丁氧羰基保护二级氨后,与丝氨酸甲酯脱水缩合生成N-(4-二苯胺苯甲基)-N-叔丁氧羰基-甘氨酰丝氨酸甲酯,脱去保护基后得到标题化合物。用~1HNMR、^(13)CNMR、IR、MASS、HRMS和HPLC对目标化合物的结构进行了表征。
In this paper,2-（4-（diphenylamino） benzylamino） acetic acid was synthesized by using glycine and 4-diphenylaminobenzaldehyde as starting materials through the reductive amination.The secondary amine of 2-（4-（diphenylamino） benzylamino）acetic acid was first protected by tert-butyloxycarbonyl,then was converted to N-（4-（diphenylamino） benzyl）-N-（tert-butoxycarbonyl）-glycylserine methyl ester through condensation with L-serine methyl ester hydrochloride.After deprotection,the target compound of N-（4-（dip-henylamino） benzyl）-glycylserine methyl ester was obtained.As-obtained compound was thoroughly characterized by ^1HNMR,^13CNMR,IR,MASS,HRMS and HPLC.
出处
《化学试剂》
CAS
北大核心
2017年第4期425-426,430,共3页
Chemical Reagents
基金
大同大学博士科研启动经费资助项目(25-17)
