氢吗啡酮联合舒芬太尼用于脊柱手术的超前镇痛效果评价被引量：16

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摘要目的探讨氢吗啡酮联合舒芬太尼用于骨科脊柱手术超前镇痛的临床应用效果评价。方法选取需择期接受脊柱手术治疗患者120例,随机分成4组(n=30),于手术开始前10 min,H1组:静脉给予20μg/kg氢吗啡酮;H2组:静脉给予30μg/kg氢吗啡酮;H3组:静脉给予40μg/kg氢吗啡酮;对照组(C组):静脉给予相同剂量的生理盐水。各组患者缝皮前10 min,均追加给予0.1μg/kg舒芬太尼。术中麻醉前(S1)、手术开始前10 min(S2)、手术开始时(S3)、手术开始后10 min(S4)和手术开始后30 min(S5)监测并记录患者生命体征(心率、血压和血氧饱和度);术后分别于拔除气管导管后10 min(T1)、30 min(T2)、1 h(T3)、2 h(T4)、4 h(T5)、6 h(T6)、12 h(T7)、24 h(T8)随访记录VAS评分和术后不良反应。结果与其他3组比较,对照组S3和S4时点的心率和血压明显升高(P<0.05);各时点,H1组、H2组和H3组组间比较,差异无统计学意义(P>0.05)。T1~T5时点,H1组、H2组和H3组分别与C组比较,VAS评分明显低于C组(P<0.05);T6和T7时点,H1组、H2组和H3组分别与C组比较,差异无统计学意义(P>0.05)。对照组术后躁动率明显升高,H3组皮肤瘙痒率明显升高。结论术中静脉给药20~40μg/kg氢吗啡酮联合舒芬太尼用于脊柱手术超前镇痛,能取得术中和术后较好的镇痛效果,而30μg/kg剂量的氢吗啡酮既能取得较良好的镇痛效果,又具有较少的不良反应,推荐使用。

作者王军霞张宏

机构地区武汉市红十字会医院麻醉科

出处《广东医学》 CAS 北大核心 2017年第6期949-951,共3页 Guangdong Medical Journal

关键词氢吗啡酮舒芬太尼脊柱手术超前镇痛

分类号 R719.82 [医药卫生—妇产科学]

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参考文献1

1崔永武,吕厚山,张琳,杜燕,廖敏华.氢吗啡酮在骨科手术后自控镇痛的临床观察[J].中华临床医师杂志（电子版）,2015,9(1):140-142. 被引量：27

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