摘要
目的探讨CT引导下^(125)I粒子组织间植入治疗晚期非小细胞肺癌的临床效果。方法选取2012年9月至2014年6月间海南省海口市人民医院收治的100例晚期非小细胞肺癌患者,在CT引导下植入^(125)I,术后2个月和6个月时复查胸部CT评估疗效,观察患者术后并发症。结果植入病例全部成功,术后13例患者达完全缓解(CR),55例患者部分缓解(PR),20例患者稳定(SD),12例患者为进展(PD),总有效率达到88.0%,1年生存率为59.0%,中位无疾病进展时间为12个月。术后并发症:气胸7例,痰中带血9例,胸腔积液9例,白细胞下降4例,经对症处理均好转。结论 CT引导下^(125)I粒子组织间植入治疗晚期非小细胞肺癌疗效好,无严重并发症。
Objective To investigate the efficacy of CT Guided ^125I seed implantation in the treatment of advanced non-small lung cancer. Methods From September 2012 to June 2014,100 patients with advanced non-small lung cancer treated at Haikou Municipal People＇s Hospital were selected. CT guided^125I seed implantation was performed on patients. The efficacy and complications was regularly followed-up for efficacy of CT evaluation at 2 and 6 months after^125I seeds implantation. Results All patients successfully completed the implantation. Thirteen patients achieved complete response（ CR）,55 had partial response（ PR）,20 showed stable disease（ SD） and 12 had progression disease（ PD）. The overall response rate was88. 0% and1 year survival rate was 59. 0%. Median progression-free survival（ PFS） was 12 months. Complications included pneumothorax（ 7 patients）,bloody sputum（ 9 patients）,pleural effusion（ 9 patients）and decreased leucocyte（ 4 patients） which improved after treatment. Conclusion CT guided^125I seed implantation is a highly effective treatment without severe complications for advanced non-small lung cancer.
出处
《中国肿瘤临床与康复》
2017年第3期302-304,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
基金
基金项目:晚期肺癌125I粒子植入治疗的研究(琼卫2012ZD-10)
关键词
^125碘
晚期
癌
非小细胞肺
治疗效果
Iodine-125
Advanced stage
Carcinoma
non-small cell lung
Efficacy
