摘要
目的观察补心气汤治疗冠心病合并抑郁症的临床疗效。方法将64例冠心病合并抑郁症患者随机分为2组,对照组32例予西医常规治疗,治疗组32例在对照组治疗基础上应用补心气汤治疗。2组均治疗4周后,比较2组治疗前后汉密尔顿焦虑量表(HAMA)评分及汉密尔顿抑郁量表(HAMD)评分变化,比较2组心绞痛疗效、心电图疗效、中医症状疗效、抑郁症疗效及不良反应发生率。结果 2组治疗后HAMA评分、HAMD评分均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。治疗组心绞痛总有效率87.50%,对照组75.00%;治疗组心电图总有效率87.50%,对照组71.87%;治疗组中医症状总有效率84.37%,对照组75.00%;治疗组抑郁症总有效率93.75%,对照组78.12%;2组总有效率比较差异均有统计学意义(P<0.05),治疗组心绞痛疗效、心电图疗效、中医症状疗效、抑郁症疗效均优于对照组。治疗组不良反应发生率6.25%,对照组9.38%,治疗组不良反应发生率低于对照组(P<0.05)。结论补心气汤治疗冠心病合并抑郁症临床效果显著。
Objective To observe the clinical effects of Supplementing heart - Qi decoction on the treatment of coronary heart disease （CHD） with depression. Methods 64 CHD patients with depression were randomly divid-ed into two groups, the control group （n = 32） was treated by conventional western medicine and the treatment group （n = 32） was treated by Supplementing heart - Qi decoction. The scores of Hamilton Anxiety Scale （ HAMA） and the Hamilton Depression Scale （HAMD） between before and after 4 weeks treatment were compared in two groups. The effects of angina and electrocardiogram （ECG） , the curative effects of traditional Chinese medicine （TCM） symptoms and depression, and the incidence rate of adverse reactions were compared between two groups after 4 weeks treat-ment. Results The scores of HAMA and HAMD after treatment were decreased in the two groups （P 〈0. 05） , and decrease in treatment group was more significantly （P 〈 0. 05 ） . The total effective rate of angina in treatment and control group was 87. 50% and 75.00% respectively, the total effective rate of ECG was 87. 50% and 71. 87% re-spectively ,the total effective rate of TCM symptoms was 84. 37% and 75.00% respectively, and the total effective rate of depression was 93.75% and 78. 12% respectively. The effects of angina, ECG, TCM symptoms and depres-sion in treatment group were superior to those in control group （P 〈 0. 05 ） . The adverse reaction rate in treatment group （6.25% ） was lower than that in control group （9.38%, P〈0.05）. Conclusion The Supplementing heart -Qi decoction has significant curative effects on the treatment of CHD with depression.
出处
《河北中医》
2017年第2期185-189,共5页
Hebei Journal of Traditional Chinese Medicine
基金
河北省中医药管理局2016年度中医药类科研计划课题(编号:2016117)
河北省沧州市科技计划项目(编号:151302047)
关键词
冠心病
抑郁症
中药疗法
Coronary heart disease
Depression
Traditional Chinese medicine
