摘要
目的探讨雾化吸入联合无创正压通气(NPPV)对慢性阻塞性肺疾病(COPD)合并呼吸衰竭患者免疫功能及血小板衍生生长因子(PDGF-β)表达的影响。方法 COPD合并呼吸衰竭患者86例随机分为观察组与对照组,每组43例,其中对照组采用常规雾化吸入治疗,观察组则在对照组基础上加用无创通气治疗。对比2组治疗前后患者免疫功能(Ig A、Ig G、C3)、PDGF-β水平以及治疗效果[呼吸困难指数(MMRS)、圣乔治问卷评分(SGRP)、6 min步行距离、第1秒呼气量占用力肺活量百分比(FEV1%)、血氧分压(PaO_2)、血二氧化碳分压(Pa CO2)]差异。结果治疗后,观察组SGRQ评分、MMRC评分以及6 min行走评分均明显低于对照组(P<0.05);治疗后,观察组FEV1%、PaO_2值明显高于对照组,Pa CO2值明显低于对照组;观察组免疫功能指标Ig A、Ig G、C3均显著高于对照组。治疗后,2组患者PDGF-β水平明显降低,且观察组PDGF-BB水平明显低于对照组(P<0.05)。治疗期间,观察组死亡率明显低于对照组,但差异无统计学意义(P>0.05)。结论雾化吸入联合NPPV能够显著改善COPD合并呼吸衰竭患者的肺部功能,调节患者免疫功能,有效改善预后。
Objective To investigate the influences of atomization inhalation combined with non-invasive positive pressure ventilation（NPPV） on immune function and platelet derived growth factor-β（PDGF-β） in patients with chronic obstructive pulmonary disease（COPD） complicated by respiratory failure.Methods Eighty-six patients with COPD complicated by respiratory failure who wer e admitted and treated in our hospital from 2013 to 2015 were randomly divided into observation group（n = 43） and control group（n = 43）.The patients in control group were treated by routine atomization inhalation,however,the patients in observation group,on the basis of control group,were treated by NPPV.The immune function indexes（Ig A,Ig G,C3）,PDGF-β levels and therapeutic effects were observed and compared between two groups.Results After treatment,the SGRQ score,MMRC score,6-min walking score in observation group were significantly lower than those in control group（53.01 ± 4.28 vs 55.71 ± 4.09,2.79 ± 0.31 vs 3.05 ± 0.36,1.33 ± 0.32 vs 1.51 ± 0.39,respectively,P〈0.05）.After treatment,the FEV1% value and PaO_2 value in observation group were significantly higher than those in control group（42.22 ± 3.07 vs 40.05 ± 3.01,66.93 ± 2.38 vs 61.50 ± 2.91,respectively）,however,Pa CO2 values were significantly lower than those in control group（51.78 ± 2.43 vs 56.03 ± 3.15）.The levels of Ig A,Ig G,C3 in observation group were significantly lower than those in control group（2.52 ± 0.9 vs 1.72 ± 0.8,14.7 ± 3.2 vs 11.7 ± 2.5,1.50 ± 0.4 vs 1.25 ± 0.5,respectively）.After treatment,PDGF-β levels were obviously decreased in both groups,moreover,the PDGF-β levels in observation group were significantly lower than those in control group（P〈0.05）.During treatment,the death rate in observation group was lower than that in control group,but there was no significant difference between two groups（P〈0.05）.Conclusion The atomization inhalation combined with non-invasive positive pressure ventilation can obviously improve pulmonary function of patients with COPD complicated by respiratory failure,and can regulate immune function and improve effectively patient＇s prognosis.
出处
《河北医药》
CAS
2017年第7期998-1001,共4页
Hebei Medical Journal
关键词
无创通气
COPD
呼吸衰竭
免疫功能
血小板衍生生长因子
non-invasive positive pressure ventilation
COPD
respiratory failure
immune function
platelet derived growth factor
