摘要
目的分析肺癌患者血清多肽特异性抗原（TPS）、癌胚抗原（CEA）、糖链抗原242（CA242）、解整合素金属蛋白酶8（ADAM8）水平变化及其临床意义。方法选取2011年7月—2013年7月在广州医科大学附属第二医院经病理学检查证实的肺癌患者100例,其中腺癌45例,鳞癌39例,小细胞肺癌16例;Ⅰ期21例,Ⅱ期12例,Ⅲ期54例,Ⅳ期13例。另选取同期收治的肺部良性病变患者40例。比较不同病理类型肺癌患者血清TPS、CEA、CA242和ADAM8水平及其阳性率,肺部良性病变患者、不同分期肺癌患者血清TPS、CEA、CA242和ADAM8水平及其阳性率,不同治疗效果肺癌患者血清TPS、CEA、CA242和ADAM8水平。结果鳞癌患者血清TPS、CA242水平高于腺癌及小细胞肺癌患者（P〈0.05）,而腺癌与小细胞肺癌患者血清TPS、CA242水平比较,差异均无统计学意义（P〉0.05）;腺癌患者血清CEA水平高于鳞癌及小细胞肺癌患者（P〈0.05）,而鳞癌与小细胞肺癌患者血清CEA水平比较,差异无统计学意义（P〉0.05）。不同病理类型肺癌患者血清ADAM8水平比较,差异无统计学意义（P〉0.05）。鳞癌患者TPS阳性率高于腺癌及小细胞肺癌患者,腺癌患者TPS阳性率高于小细胞肺癌患者（P〈0.05）;腺癌患者CEA阳性率高于鳞癌及小细胞肺癌患者,小细胞肺癌患者CEA阳性率高于鳞癌患者（P〈0.05）;小细胞肺癌患者CA242阳性率高于鳞癌及腺癌患者,鳞癌患者CA242阳性率高于腺癌患者（P〈0.05）;小细胞肺癌患者ADAM8阳性率高于鳞癌及腺癌患者,腺癌患者ADAM8阳性率高于鳞癌患者（P〈0.05）。Ⅲ-Ⅳ期肺癌患者血清TPS、CEA、CA242和ADAM8水平高于肺部良性病变及Ⅰ-Ⅱ期肺癌患者,Ⅰ-Ⅱ期肺癌患者血清TPS、CA242和ADAM8水平高于肺部良性病变患者（P〈0.05）;Ⅰ-Ⅱ期肺癌患者与肺部良性病变患者血清CEA水平比较,差异无统计意义（P〉0.05）。Ⅲ-Ⅳ期肺癌患者TPS、CEA、CA242和ADAM8阳性率高于肺部良性病变及Ⅰ-Ⅱ期肺癌患者,Ⅰ-Ⅱ期肺癌患者TPS、CEA和ADAM8阳性率高于肺部良性病变患者（P〈0.05）;Ⅰ-Ⅱ期肺癌患者与肺部良性病变患者CA242阳性率比较,差异无统计意义（P〉0.05）。治疗有效的肺癌患者血清TPS、CEA、CA242和ADAM8水平均高于治疗无效的肺癌患者（P〈0.05）。结论肺癌患者血清TPS、CEA、CA242和ADAM8水平及阳性率明显升高,检测TPS、CEA、CA242和ADAM8有利于鉴别肺部良恶性病变,判断肺癌病理类型及治疗结果等。
Objective To analyze the changes and clinical significance of serum levels of TPS,CEA,CA242 and ADAM8 of patients with lung cancer. Methods A total of 100 lung cancer patients confirmed by pathological examination were selected in the Second Affiliated Hospital of Guangzhou Medical University from July 2011 to July 2013,thereinto 45 cases with adenocarcinoma were served as A1 group,39 cases with squamous carcinoma were served as A2 group,16 cases with small cell lung carcinoma were served as A3 group; 21 cases with stageⅠ and 12 cases with stage Ⅱwere served as B1 group,54 cases with stage Ⅲ and 13 cases with stage Ⅳ were served as B2 group. A total of 40 patients with benign pulmonary disease were selected as control group at the same time. Serum levels and positive rates of TPS,CEA,CA242 and ADAM8 were compared in lung cancer patients with different pathological types,in patients with benign pulmonary disease and lung cancer patients with different clinical stages,meanwhile serum levels of TPS,CEA,CA242 and ADAM8 were compared in lung cancer patients with different treatment outcome. Results Serum levels of TPS and CA242 of A2 group were statistically significantly higher than those of A1 group and A3 group（ P 〈 0. 05）,while no statistically significant differences of serum level of TPS or CA242 was found between A1 group and A3 group（ P 〉 0. 05）; serum CEA level of A1 group was statistically significantly higher than that of A2 group and A3 group,respectively（ P 〈 0. 05）,while no statistically significant differences of serum CEA level was found between A2 group and A3 group（ P 〉 0. 05）. No statistically significant differences of serum ADAM8 level was found among the four groups（ P 〉 0. 05）. Positive rate of TPS of A2 group was statistically significantly higher than that of A1 group and A3 group,respectively,meanwhile positive rate of TPS of A1 group was statistically significantly higher than that of A3 group（ P 〈0. 05）; positive rate of CEA of A1 group was statistically significantly higher than that of A2 group and A3 group,respectively,meanwhile positive rate of CEA of A3 group was statistically significantly higher than that of A2 group（ P 〈 0. 05）; positive rate of CA242 of A3 group was statistically significantly higher than that of A1 group and A2 group,respectively,meanwhile positive rate of CA242 of A2 group was statistically significantly higher than that of A1 group（ P 〈 0. 05）; positive rate of ADAM8 of A3 group was statistically significantly higher than that of A1 group and A2 group,respectively,meanwhile positive rate of CA242 of A1 group was statistically significantly higher than that of A2 group（ P 〈 0. 05）. Serum levels of TPS, CEA, CA242 and ADAM8 of B2 group were statistically significantly higher than those of control group,B1 group（ P 〈 0. 05）; serum levels of TPS,CA242 and ADAM8 of B1 group were statistically significantly higher than those of control group（ P 〈 0. 05）,while no statistically significant differences of serum CEA level was found between control group and B1 group（ P 〉 0. 05）. Positive rates of TPS,CEA,CA242 and ADAM8 of B2 group were statistically significantly higher than those of control group,B1 group（ P〈 0. 05）; positive rates of TPS,CEA and ADAM8 of B1 group were statistically significantly higher than those of control group（ P 〈 0. 05）,while no statistically significant differences of positive rate of CA242 was found between control group and B1 group（ P 〉 0. 05）. Serum levels of TPS,CEA,CA242 and ADAM8 of lung cancer patients with effective treatment outcome were statistically significantly higher than those of lung cancer patients with non-effective treatment outcome（ P 〈 0. 05）.Conclusion Serum levels and positive rates of TPS, CEA, CA242 and ADAM8 of lung cancer patients are significantly elevated,detection of TPS,CEA,CA242 and ADAM8 is helpful to differentiate benign and malignant pulmonary disease,judge the pathological types and treatment outcome.
出处
《实用心脑肺血管病杂志》
2016年第B12期62-65,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
肺肿瘤
癌胚抗原
多肽特异性抗原
糖链抗原242
解整合素金属蛋白酶8
Lung neoplasms
Carcinoembryonic antigen
Polypeptide specific antigen
Carbohydrate antigen 242
disintegrin metalloproteinase 8
