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替加环素治疗泛耐药鲍曼不动杆菌所致重症肺炎的疗效分析 被引量:3

Efficacy of Tigecycline in the Treatment of Severe Pneumonia Caused by Pan-resistant Acinetobacter Baumannii
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摘要 目的探讨替加环素治疗泛耐药鲍曼不动杆菌所致重症肺炎的治疗效果。方法选取2014年1月—2016年1月在内蒙古医科大学附属医院治疗的泛耐药鲍曼不动杆菌所致重症肺炎患者60例,采用抛硬币的方法将其分为试验组和对照组,各30例。患者均接受头孢哌酮舒巴坦钠静脉滴注治疗,试验组患者同时给予替加环素治疗,比较两组治疗效果,并记录两组治疗前后白细胞计数(WBC)和C反应蛋白(CRP)水平。结果试验组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,试验组CRP低于对照组,差异有统计学意义(P<0.05)。试验组治疗后WBC和CRP以及对照组治疗后CRP均低于治疗前,差异有统计学意义(P<0.05)。结论替加环素联合头孢哌酮舒巴坦静脉滴注治疗泛耐药鲍曼不动杆菌所致重症肺炎有助于提高临床治疗效果,改善患者临床症状。 Objective To explore the efficacy of tigecycline in the treatment of severe pneumonia caused by pan-resistant acinetobacter baumannii. Methods From January 2014 to January 2016,60 patients with severe pneumonia caused by pan-resistant acinetobacter baumannii admitted to the Affiliated Hospital of Inner Mongolia Medical University were randomly divided into the experimental group( n = 30) and the control group( n = 30). All patients were treated with cefoperazone and sulbactam intravenously,while the patients in the experimental group was treated with tigecycline,and the effects of different treatment regimens were compared. The level of WBC and CRP before and after treatment were recorded. Results Compared with the control group,the total effective rate of the experimental group was significantly higher( P 〈 0. 05). The CRP of the experimental group was significantly lower than that of the control group after treatment( P 〈 0. 05). The WBC and CRP after treatment were lower than those before treatment in experimental group( P 〈 0. 05). The CRP after treatment was lower than that before treatment in control group( P 〈 0. 05). Conclusion Intravenous infusion of tigecycline combined with cefoperazone and sulbactam in the treatment of severe pneumonia caused by pan-resistant acinetobacter baumannii can improve the clinical efficacy and symptoms.
出处 《实用心脑肺血管病杂志》 2016年第B12期101-103,共3页 Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词 肺炎 泛耐药鲍曼不动杆菌 头孢哌酮舒巴坦 替加环素 治疗结果 Pneumonia Pan-resistant acinetobacter baumannii Cefoperazone sulbactam Tigecycline Treatment outcome
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